ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Primary antibiotic resistance and its relationship with cagA and vacA genes in Helicobacter pylori isolates from Algerian patients.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Clarithromycin-resistant Helicobacter pylori in Africa: a systematic review and meta-analysis.Antimicrobial resistance and infection control · 2025Pooled it
- The prevalence of clarithromycin-resistantPeerJ · 2023Pooled it
- Clinical relevance of the cagA and vacA s1m1 status and antibiotic resistance in Helicobacter pylori: a systematic review and meta-analysis.BMC infectious diseases · 2022Pooled it
- Immunohistochemistry and molecular detection of Helicobacter pylori infection and their virulent genes in gastric biopsies.Scientific reports · 2026Article
- Detection of virulence genes in Helicobacter pylori and its correlation with drug resistance by polymerase chain reaction.European journal of medical research · 2025Article
- The therapeutic potential ofTurkish journal of biology = Turk biyoloji dergisi · 2025Article
- Molecular Characterization of Antimicrobial Resistance and Virulence Genotyping amongInfectious disorders drug targets · 2025Article
- Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology.BMC infectious diseases · 2024Article
- Relationship between antibiotic resistance and the cagA and vacA genotypes among Helicobacter pylori strain isolates from patients in Xi'an.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Antibiotic resistance in Helicobacter pylori: From potential biomolecular mechanisms to clinical practice.Journal of clinical laboratory analysis · 2023Review
- Prevalence of OralClinical and experimental gastroenterology · 2023Article
- Comparative Study of Helicobacter Pylori Resistance to Clarithromycin and Metronidazole and Its Association with Epidemiological Factors in A Moroccan Population.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Study on the value of antibiotic-resistant gene detection inExperimental and therapeutic medicine · 2022Article
- Article
- Genotyping ofInternational journal of microbiology · 2021Article
- Review
- Article
- Infections withWorld journal of gastroenterology · 2019Review
- DifferentialPathogens (Basel, Switzerland) · 2019Article
- Increase in antibiotic resistantInfection and drug resistance · 2019Article
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7 authors.
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Abstract
The epidemiology of Helicobacter pylori resistance to antibiotics is poorly documented in Africa and especially in Algeria. The aim of our study was to determine the antibiotic resistance rates, as well as its possible relationship with VacA and CagA virulence markers of isolates from Algerian patients. One hundred and fifty one H. pylori isolate were obtained between 2012 and 2015 from 200 patients with upper abdominal pain. Antimicrobial susceptibility testing was performed for amoxicillin, clarithromycin, metronidazole, ciprofloxacin, rifampicin and tetracycline. Molecular identification of H. pylori and the detection of vacA and cagA genes were performed using specific primers. We found that H. pylori was present in 83.5% of collected biopsies, 54.9% of the samples were cagA positive, 49.67% were vacA s1m1, 18.30% were vacA s1m2 and 25.49% were vacA s2m2. Isolates were characterized by no resistance to amoxicillin (0%), tetracycline (0%), rifampicin (0%), a high rate of resistance to metronidazole (61.1%) and a lower rate of resistance to clarithromycin (22.8%) and ciprofloxacin (16.8%). No statically significant relationship was found between vagA and cagA genotypes and antibiotic resistance results (p>0.5) except for the metronidazole, which had relation with the presence of cagA genotype (p=0.001).
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