Observational studyBritish journal of anaesthesia2018
Norepinephrine exerts an inotropic effect during the early phase of human septic shock.
Observational study in British journal of anaesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Norepinephrine Exerts an Inotropic Effect at the Early Phase of Human Septic
Hemodynamic Effects of Dopamine Versus Norepinephrine Under General Anesthesia in Infant With Congenital Heart Disease
Effect of Vasopressin on Kidney and Cardiac Function in Previously Hypertensive Patients With Septic Shock: A Randomized Clinical Trial
Inotropic Effects of Vasopressin Versus Noradrenaline In Patients With Vasoplegic Syndrome After Cardiac Surgery
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Association of noradrenaline dose with mortality in critically ill patients: a systematic review and dose-response meta-analysis.Critical care (London, England) · 2025Pooled it
- Outcomes of VA-ECMO with and without Left Centricular (LV) Decompression Using Intra-Aortic Balloon Pumping (IABP) versus Other LV Decompression Techniques: A Systematic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2020Pooled it
- Effects of two different partial pressure of end-tidal carbon dioxide levels on cardiac function in patients undergoing carotid endarterectomy: a randomized controlled trial.BMC anesthesiology · 2025Trial
- Effects of very early start of norepinephrine in patients with septic shock: a propensity score-based analysis.Critical care (London, England) · 2020Trial
- Severe Burn Injury Alters Expression of Adrenergic Receptor Transcripts in a Rodent Model.European burn journal · 2026Article
- A structured 5-question approach for echocardiographic evaluation of undifferentiated shock.Echo research and practice · 2026Review
- The usual suspects: a pragmatic framework to identify and address reversible contributors in apparent refractory septic shock.Critical care (London, England) · 2026Review
- Current and future strategies aiming at reducing catecholamine exposure in septic shock.Critical care (London, England) · 2026Review
- Optimizing Timing and Dose of Starting Norepinephrine and Vasopressin in Septic Shock.Life (Basel, Switzerland) · 2026Review
- Proof of concept of noninvasive detection of norepinephrine induced stroke volume changes using perfusion index in cardiac surgery.Scientific reports · 2026Observational
- Effect of norepinephrine on ventricular systolic function during septic shock: the ENESySS study.Journal of anesthesia, analgesia and critical care · 2026Article
- Time-to-vasopressors and clinical outcome by level of diastolic blood pressure and pulse pressure in patients with septic shock: a retrospective analysis of prospective multicenter cohort study.Critical care (London, England) · 2026Article
- Experts' recommendations for the management of adult patients with cardiogenic shock.Annals of intensive care · 2026Article
- Current standard of care for septic shock.Intensive care medicine · 2026Review
- The time course of fluid responsiveness.Annals of intensive care · 2026Review
- Norepinephrine use at extubation in critically ill patients with obesity: a cohort study with multicenter validation.Intensive care medicine · 2025Observational
- Intravenous Levosimendan for Acute Heart Failure with Renal Impairment Following Severe Scorpion Envenomation: Case Report and Literature Review.The American journal of tropical medicine and hygiene · 2025Review
- Vasopressin and its analogues in patients with septic shock: holy Grail or unfulfilled promise?Critical care (London, England) · 2025Review
- Ability of diastolic arterial pressure to better characterize the severity of septic shock when adjusted for heart rate and norepinephrine dose.Annals of intensive care · 2025Article
- Sex- and Gender-Based Analysis on Norepinephrine Use in Septic Shock: Why Is It Still a Male World?Microorganisms · 2024Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe conducted this study to investigate whether norepinephrine increases cardiac contractility when administered during the early phase of septic shock.
methodsWe studied 38 patients with septic shock who had been resuscitated for <3 h and whose mean arterial pressure (MAP) remained <65 mm Hg. Echocardiographic variables were obtained before (T
resultsThere were significant (P<0.05) increases from T
conclusionsNorepinephrine administration during early resuscitation in patients with septic shock increased the cardiac systolic function despite the presumed increase in left ventricular afterload secondary to the increased arterial pressure. Whether such an effect persists over time remains to be evaluated. CLINICAL
trial registrationNCT02750683.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.