ArticleMolecular cell2018
The Circulating Protease Persephone Is an Immune Sensor for Microbial Proteolytic Activities Upstream of the Drosophila Toll Pathway.
Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 133 citations in OpenAlex.
- The underexplored mycobiome: insights from Drosophila into human health and disease.Antonie van Leeuwenhoek · 2026Review
- Drosophila host defense mechanisms against filamentous fungal pathogens with diverse lifestyles.PLoS pathogens · 2026Article
- α2-macroglobulin function of thioester-containing proteins guardsProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Reserpine prolongs lifespan but compromises locomotion and heat-stress resilience in Drosophila melanogaster.npj aging · 2026Article
- Layers of immunity: Deconstructing theeLife · 2025Article
- Fungal effector disables cathepsin-driven Toll immunity in insects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Fungal evasion ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- An unusual Toll/MyD88-mediatedFly · 2024Article
- Hemolymph protease-17b activates proHP6 to stimulate melanization and Toll signaling in Manduca sexta.Insect biochemistry and molecular biology · 2024Article
- A myeloid differentiation-like protein in partnership with Toll5 from the pest insectProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The endosymbiontmBio · 2024Article
- Innate immunity inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Identification of immunity-related genes distinctly regulated by Manduca sexta Spӓtzle-1/2 and Escherichia coli peptidoglycan.Insect biochemistry and molecular biology · 2024Article
- The transcriptional response in mosquitoes distinguishes between fungi and bacteria but not Gram types.BMC genomics · 2024Article
- An evolutionarily conserved serine protease network mediates melanization and Toll activation inScience advances · 2023Article
- AVirulence · 2023Article
- Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies.PLoS genetics · 2023Article
- Regulating metabolism to shape immune function: Lessons from Drosophila.Seminars in cell & developmental biology · 2023Review
- A Toll pathway effector protectsProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L.Scientific reports · 2022Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial or endogenous molecular patterns as well as pathogen functional features can activate innate immune systems. Whereas detection of infection by pattern recognition receptors has been investigated in details, sensing of virulence factors activities remains less characterized. In Drosophila, genetic evidences indicate that the serine protease Persephone belongs to a danger pathway activated by abnormal proteolytic activities to induce Toll signaling. However, neither the activation mechanism of this pathway nor its specificity has been determined. Here, we identify a unique region in the pro-domain of Persephone that functions as bait for exogenous proteases independently of their origin, type, or specificity. Cleavage in this bait region constitutes the first step of a sequential activation and licenses the subsequent maturation of Persephone to the endogenous cysteine cathepsin 26-29-p. Our results establish Persephone itself as an immune receptor able to sense a broad range of microbes through virulence factor activities rather than molecular patterns.
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