Trial reportNutrition journal2018
High phosphorus intake and gut-related parameters - results of a randomized placebo-controlled human intervention study.
Trial report in Nutrition journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02095392 (The Effect of Soluble Phosphate in Combination With Different Calcium Doses on Calcium and Phosphorus Metabolism in Healthy Adults), which is not on this map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Soluble Phosphate in Combination With Different Calcium Doses on Calcium and Phosphorus Metabolism in Healthy Adults
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Vitamin D and the gut microbiome: a systematic review of in vivo studies.European journal of nutrition · 2019Pooled it
- Pooled it
- Pooled it
- Gut microbiome in hemodialysis patients treated with calcium acetate or treated with sucroferric oxyhydroxide: a pilot study.International urology and nephrology · 2022Trial
- Association between Phosphate Binders and Constipation in Patients Undergoing Chronic Hemodialysis: A Cross-sectional Study.Internal medicine (Tokyo, Japan) · 2026Article
- High-altitude mountaineering induces adaptive gut microbiome shifts associated with dietary intake and performance markers.Scientific reports · 2025Article
- A Comprehensive Review of the Triangular Relationship Among Diet, Gut Microbiota, and Aging.International journal of molecular sciences · 2025Review
- Milk mineral composition is strongly associated with the human milk microbiome.Frontiers in nutrition · 2025Article
- Beneficial microbiome and diet interplay in early-onset colorectal cancer.EMBO molecular medicine · 2025Review
- A Comprehensive Review of the Triangular Relationship among Diet-Gut Microbiota-Inflammation.International journal of molecular sciences · 2024Review
- Impact of Novel Foods on the Human Gut Microbiome: Current Status.Microorganisms · 2024Review
- Triangulating nutrigenomics, metabolomics and microbiomics toward personalized nutrition and healthy living.Human genomics · 2023Review
- Clinical Perspectives of Gut Microbiota in Patients with Chronic Kidney Disease and End-Stage Kidney Disease: Where Do We Stand?Biomedicines · 2023Review
- The Associations between Multiple Essential Metal(loid)s and Gut Microbiota in Chinese Community-Dwelling Older Adults.Nutrients · 2023Article
- Functional Gastrointestinal Disorders with Psychiatric Symptoms: Involvement of the Microbiome-Gut-Brain Axis in the Pathophysiology and Case Management.Microorganisms · 2022Review
- Mineral-Enriched Postbiotics: A New Perspective for Microbial Therapy to Prevent and Treat Gut Dysbiosis.Biomedicines · 2022Review
- Review
- Gut microbiome-micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?BioFactors (Oxford, England) · 2022Review
- Effects of Dietary Nutrients on Fatty Liver Disease Associated With Metabolic Dysfunction (MAFLD): Based on the Intestinal-Hepatic Axis.Frontiers in nutrition · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, high phosphate intakes were discussed critically. In the small intestine, a part of the ingested phosphate and calcium precipitates to amorphous calcium phosphate (ACP), which in turn can precipitate other intestinal substances, thus leading to a beneficial modulation of the intestinal environment. Therefore, we analysed faecal samples obtained from a human intervention study regarding gut-related parameters.
methodsSixty-two healthy subjects (men, n = 30; women, n = 32) completed the double-blind, placebo-controlled and parallel designed study (mean age: 29 ± 7 years; mean BMI: 24 ± 3 kg/m
resultsFaecal fat concentrations did not change significantly due to the interventions. Concentrations of faecal total SCFA and acetate were significantly higher after 8 weeks of P1000/Ca500 supplementation compared to the P1000/Ca0 supplementation. In men, faecal total SCFA and acetate concentrations were significantly higher after 8 weeks in the P1000/Ca1000 group compared to the P1000/Ca0 one. None of the interventions markedly affected cyto- and genotoxic activity of FW. Men of the P1000/Ca1000 intervention had a significantly different gut microbial community compared to the men of the P1000/Ca0 and P1000/Ca500 ones. The genus Clostridium XVIII was significantly more abundant in men of the P1000/Ca1000 intervention group compared to the other groups. Supplementations did not cause increased intestinal distress.
conclusionsThe used high phosphorus diet did not influence cyto- and genotoxicity of FW and the concentrations of faecal fat independent of calcium intake. Our study provides first hints for a potential phosphorus-induced modulation of the gut community and the faecal total SCFA content.
trial registrationThe trial is registered at ClinicalTrials.gov as NCT02095392 .
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