Trial reportEuropean heart journal2018
Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial.
Trial report in European heart journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 170 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feedback Intervention and Treatment Times in ST- Elevation Myocardial Infarction (FITT-STEMI): A Multicenter Trial Analyzing the Effects of Systematic Data Feedback on Treatment Quality and Survival Rates.
RUral dispaRities in prehospitAL STEMI
Who cites it
170 citing papers in PubMed, 2 syntheses or guidelines pooled it, 358 citations in OpenAlex.
- Comparison of the Characteristics, Management, and Outcomes of STEMI Patients Presenting With vs. Those of Patients Presenting Without COVID-19 Infection: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Infarction-Related Cardiogenic Shock- Diagnosis, Monitoring and Therapy–A German-Austrian S3 Guideline.Deutsches Arzteblatt international · 2021Guideline
- Infarct-Related Artery as a Donor of Collaterals in ST-Segment-Elevation Myocardial Infarction With Concomitant Chronic Total Occlusion: Challenge of the Double-Jeopardy Thesis.Journal of the American Heart Association · 2023Trial
- Patient delay and benefit of timely reperfusion in ST-segment elevation myocardial infarction.Open heart · 2021Trial
- Three doors, three locks: a domain-specific framework for the residual door-to-balloon gap in STEMI care : Matters Arising, commentary on Krishnan et al., Int J Emerg Med 2026;19:113.International journal of emergency medicine · 2026Article
- Pre-hospital heparin is not associated with infarct vessel patency and mortality in ST-segment elevation myocardial infarction patients with out-of-hospital cardiac arrest.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Risk, Management, and Outcomes in PCI-Treated Acute Coronary Syndrome With Cardiogenic Shock.JACC. Advances · 2026Article
- Predictors of a prolonged puncture-wire time in patients with ST-Elevation Myocardial Infarction (STEMI).BMC cardiovascular disorders · 2026Article
- Spontaneous Coronary Reperfusion in STEMI After Pre-Hospital Loading Dose of Triple Antithrombotic Therapy.Clinical cardiology · 2026Observational
- The impact of primary percutaneous coronary intervention timing on prognosis in STEMI patients.Clinical medicine (London, England) · 2026Article
- Temporal improvements in prehospital systems-of-care for ST-elevation myocardial infarction patients in Victoria, Australia: a retrospective study.BMC emergency medicine · 2026Article
- Radial versus femoral access for coronary angiography and percutaneous coronary interventions in critically ill patients.Journal of anesthesia, analgesia and critical care · 2026Article
- Association of door-to-reperfusion time with in-hospital mortality in shockable-rhythm out-of-hospital cardiac arrest undergoing primary percutaneous coronary intervention.Resuscitation plus · 2026Article
- Exploration of the Clinical Assessment and Prognostic Value of Society for Cardiovascular Angiography and Intervention Shock Staging in Patients With Acute Myocardial Infarction and Cardiogenic Shock on Veno-arterial Extracorporeal Membrane Oxygenation Support.Reviews in cardiovascular medicine · 2026Article
- Challenges of Intra-Aortic Balloon Pump and Extracorporeal Membrane Oxygenation in Cardiogenic Shock: Real-World Outcomes.Acta Cardiologica Sinica · 2026Article
- Impact of automated dispensing cabinets on medication administration efficiency in the emergency department.BMC emergency medicine · 2026Observational
- Urgent samples in clinical laboratories: stochastic batching to minimize patient turnaround time.Health care management science · 2026Article
- Persistent Sex Disparities in Pre-Hospital Delay Among Patients With STEMI Despite Overall Improvements: Findings From the Chinese Cardiovascular Association Chest Pain Center Registry.Journal of the American Heart Association · 2026Article
- Article
- [The Cardiac Arrest Receiving Team based on the Freiburg model : Structuring of postresuscitation care following nontraumatic, out-of-hospital cardiac arrest in an interdisciplinary team].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Review
110 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 16 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: The aim of this study was to investigate the effect of contact-to-balloon time on mortality in ST-segment elevation myocardial infarction (STEMI) patients with and without haemodynamic instability. Methods and results: Using data from the prospective, multicentre Feedback Intervention and Treatment Times in ST-Elevation Myocardial Infarction (FITT-STEMI) trial, we assessed the prognostic relevance of first medical contact-to-balloon time in n = 12 675 STEMI patients who used emergency medical service transportation and were treated with primary percutaneous coronary intervention (PCI). Patients were stratified by cardiogenic shock (CS) and out-of-hospital cardiac arrest (OHCA). For patients treated within 60 to 180 min from the first medical contact, we found a nearly linear relationship between contact-to-balloon times and mortality in all four STEMI groups. In CS patients with no OHCA, every 10-min treatment delay resulted in 3.31 additional deaths in 100 PCI-treated patients. This treatment delay-related increase in mortality was significantly higher as compared to the two groups of OHCA patients with shock (2.09) and without shock (1.34), as well as to haemodynamically stable patients (0.34, P < 0.0001). Conclusions: In patients with CS, the time elapsing from the first medical contact to primary PCI is a strong predictor of an adverse outcome. This patient group benefitted most from immediate PCI treatment, hence special efforts to shorten contact-to-balloon time should be applied in particular to these high-risk STEMI patients. Clinical Trial Registration: NCT00794001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.