ArticleAmerican journal of epidemiology2018
Congenital Abnormalities of the Male Reproductive System and Risk of Autism Spectrum Disorders.
Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Mental health diagnoses among patients with complex hypospadias.World journal of urology · 2026Article
- Congenital Muscular Torticollis as a Potential Neonatal Marker of Autism Spectrum Disorder and Other Neurodevelopmental Conditions.Research in autism · 2026Article
- Preventive Strategies and Biomarkers in Male Reproductive Health from Multidisciplinary Perspective: Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- The association between autism spectrum disorder and congenital malformations: a population-based nested case-control study.Molecular psychiatry · 2026Article
- Maternal periconception hyperglycemia, preconception diabetes, and risk of major congenital malformations in offspring.Human reproduction (Oxford, England) · 2024Article
- Paternal Use of Metformin During the Sperm Development Period Preceding Conception and Risk for Major Congenital Malformations in Newborns.Annals of internal medicine · 2024Article
- Medication use and risk of amyotrophic lateral sclerosis: using machine learning for an exposome-wide screen of a large clinical database.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2024Article
- Diethylstilbestrol and autism.Frontiers in endocrinology · 2022Review
- Associations of Maternal Androgen-Related Conditions With Risk of Autism Spectrum Disorder in Progeny and Mediation by Cardiovascular, Metabolic, and Fertility Factors.American journal of epidemiology · 2021Article
- Diagnosis despite clinical ambiguity: physicians' perspectives on the rise in Autism Spectrum disorder incidence.BMC psychiatry · 2021Article
- Intrauterine Exposure to Acetaminophen and Adverse Developmental Outcomes: Epidemiological Findings and Methodological Issues.Current environmental health reports · 2021Review
- Climate Change, Pesticides and Health: Considering the Risks and Opportunities of Adaptation for Zimbabwean Smallholder Cotton Growers.International journal of environmental research and public health · 2020Article
- Physical health of autistic girls and women: a scoping review.Molecular autism · 2020Article
- Article
- Prenatal sex hormones and behavioral outcomes in children.Psychoneuroendocrinology · 2020Article
- Autism spectrum disorders: let's talk about glucose?Translational psychiatry · 2019Review
- Association of Exposure to Diethylstilbestrol During Pregnancy With Multigenerational Neurodevelopmental Deficits.JAMA pediatrics · 2018Article
- Invited Commentary: Male Reproductive System Congenital Malformations and the Risk of Autism Spectrum Disorder.American journal of epidemiology · 2018Article
- Fatal and Non-fatal Health Outcomes of Congenital Musculoskeletal and Limb Anomalies Among Infants in Eastern Sub-Saharan Africa, From 1990 to 2023.SAGE open nursingArticle
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6 authors at 3 institutions in 2 countries.
Funding
Abstract
Androgens have an extensive influence on brain development in regions of the brain that are relevant for autism spectrum disorder (ASD), yet their etiological involvement remains unclear. Hypospadias (abnormal positioning of the urethral opening) and cryptorchidism (undescended testes) are 2 relatively common male birth defects that are strongly associated with prenatal androgen deficiencies. Having either disorder is a proxy indicator of atypical gestational androgen exposure, yet the association between these disorders and autism has not been extensively studied. We analyzed male singleton live births (n = 224,598) occurring from January 1, 1999, through December 31, 2013, in a large Israeli health-care organization. Boys with autism, cryptorchidism, and hypospadias were identified via International Classification of Diseases, Ninth Revision, codes, with further verification of autism case status by review of medical records. In multivariable-adjusted analyses, the odds ratio for ASD among boys with either condition was 1.62 (95% confidence interval (CI): 1.44, 1.82). The odds ratio for boys with cryptorchidism only was 1.55 (95% CI: 1.34, 1.78), and that for boys with hypospadias only was 1.65 (95% CI: 1.38, 1.98). ASD risk was not elevated among unaffected brothers of hypospadias or cryptorchidism cases, despite familial aggregation of all 3 conditions, providing some indication for the possibility of pregnancy-specific risk factors driving the observed associations. Results suggest that in-utero hypoandrogenicity could play a role in ASD etiology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.