ArticleChest2018
Features of COPD as Predictors of Lung Cancer.
Article in Chest, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Lung Cancer Risk in US Adults with COPD: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- Prevalence of lung cancer in chronic obstructive pulmonary disease: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- [Study on the Benefit of Postoperative Exercise Rehabilitation in Patients with Lung Cancer Complicated with Chronic Obstructive Pulmonary Disease].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2022Trial
- Prevalence, Symptom Burden, and Underdiagnosis of Chronic Obstructive Pulmonary Disease in a Lung Cancer Screening Cohort.Annals of the American Thoracic Society · 2020Trial
- Sequential screening for lung cancer in a high-risk group: randomised controlled trial: LungSEARCH: a randomised controlled trial of Surveillance using sputum and imaging for the EARly detection of lung Cancer in a High-risk group.The European respiratory journal · 2019Trial
- Pulmonary vascular volume heterogeneity in association with emphysema: a multicenter study based on non-contrast chest CT.European radiology · 2026Article
- Impact of COPD on Lung Cancer Screening Positivity in a Specialist-Managed Cohort From Brazil.CHEST pulmonary · 2026Article
- Deep learning-based super-resolution ultrashort echo time MRI for pulmonary nodule detection and longitudinal assessment in emphysema.BMC pulmonary medicine · 2026Article
- Associations between respiratory diseases and lung cancer risk: a secondary analysis of the large-scale prospective UK biobank cohort.BMJ open respiratory research · 2026Article
- The impact of chest computed tomography-defined emphysema on extrapulmonary metastases in patients with lung cancer.BMC medical imaging · 2026Article
- COPD-Lung Cancer Comorbidity: Mechanistic Insights and Precision Oncology Implications.International journal of chronic obstructive pulmonary disease · 2026Review
- Pretraining on Chronic Lung Inflammatory Disease Datasets to Enhance Indeterminant Lung Cancer Classification using Masked Autoencoders.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026Article
- Unsupervised discovery of clinical disease signatures using probabilistic independence.Journal of biomedical informatics · 2025Article
- The association between emphysema detected on computed tomography and increased risk of lung cancer: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2025Article
- Exploring the protective role of maternal lung cancer history on allergic rhinitis.Journal of clinical biochemistry and nutrition · 2025Article
- Incidence of Lung Cancer in COPD Patients in Western Yokohama Managed by Primary Care Physicians with Hospital Collaboration.International journal of chronic obstructive pulmonary disease · 2025Article
- Completing the Puzzle: Determinants, Comorbidities and Complications for Different Lung Cancer Subtypes: A Pilot Study.Life (Basel, Switzerland) · 2024Article
- Emphysema and lung cancer risk.Translational lung cancer research · 2024Article
- Uncovering novel mechanisms of chitinase-3-like protein 1 in driving inflammation-associated cancers.Cancer cell international · 2024Review
- Thoracic high resolution computed tomography evaluation of imaging abnormalities of 108 lung cancer patients with different pulmonary function.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
Corrections and comments
- Commented on by
- Commented on byResponse.2018
Authors and funding
13 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundLung cancer is a leading cause of death and hospitalization for patients with COPD. A detailed understanding of which clinical features of COPD increase risk is needed.
methodsWe performed a nested case-control study of Genetic Epidemiology of COPD (COPDGene) Study subjects with and without lung cancer, age 45 to 80 years, who smoked at least 10-pack years to identify clinical and imaging features of smokers, with and without COPD, that are associated with an increased risk of lung cancer. The baseline evaluation included spirometry, high-resolution chest CT scanning, and respiratory questionnaires. New lung cancer diagnoses were identified over 8 years of longitudinal follow-up. Cases of lung cancer were matched 1:4 with control subjects for age, race, sex, and smoking history. Multiple logistic regression analyses were used to determine features predictive of lung cancer.
resultsFeatures associated with a future risk of lung cancer included decreased FEV
conclusionsThe degree of COPD severity, including airflow obstruction, visual emphysema, and respiratory exacerbations, was independently predictive of lung cancer. These risk factors should be further studied as inclusion and exclusion criteria for the survival benefit of lung cancer screening. Studies are needed to determine if reduction in respiratory exacerbations among smokers can reduce the risk of lung cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.