ArticlePloS one2018
The impact of "Option B" on HIV transmission from mother to child in Rwanda: An interrupted time series analysis.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Coercive public health policies need context-specific ethical justifications.Monash bioethics review · 2025Article
- Understanding rapid implementation from discovery to scale: Rwanda's implementation of rotavirus vaccines and PMTCT in the quest to reduce under-5 mortality.BMC pediatrics · 2024Article
- Determinants of comprehensive knowledge on mother-to-child transmission of HIV and its prevention among childbearing women in Rwanda: insights from the 2020 Rwandan Demographic and Health Survey.BMC public health · 2023Article
- The evaluation of preventive and control measures on congenital syphilis in Guangdong Province, China: a time series modeling study.Infection · 2022Article
- Child mortality associated with maternal HIV status: a retrospective analysis in Rwanda, 2005-2015.BMJ global health · 2021Article
- Towards elimination of mother-to-child transmission of HIV in Rwanda: a nested case-control study of risk factors for transmission.BMC pregnancy and childbirth · 2021Article
- Impact of strategic use of antiretroviral therapy intervention to the HIV continuum of care in 13 cities in Indonesia: an interrupted time series analysis.AIDS research and therapy · 2021Article
- "At home, no one knows": A qualitative study of retention challenges among women living with HIV in Tanzania.PloS one · 2020Article
- Mother-to-Child Transmission of HIV and Its Predictors Among HIV-Exposed Infants at an Outpatient Clinic for HIV/AIDS in Vietnam.HIV/AIDS (Auckland, N.Z.) · 2020Article
- Experiences of Fetal or Infant Loss among Tanzanian Women in HIV Care.Journal of loss & trauma · 2019Article
- Study of impact of WHO option B+ on maternal and perinatal outcome in HIV-positive women delivering at a tertiary care hospital, Delhi.Indian journal of sexually transmitted diseases and AIDSArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundNearly a quarter of a million children have acquired HIV, prompting the implementation of new protocols-Option B and B+-for treating HIV+ pregnant women. While efficacy has been demonstrated in randomized trials, there is limited real-world evidence on the impact of these changes. Using longitudinal, routinely collected data we assessed the impact of the adoption of WHO Option B in Rwanda on mother to infant transmission.
methodsWe used interrupted time series analysis to evaluate the impact of Option B on mother-to-child HIV transmission in Rwanda. Our primary outcome was the proportion of HIV tests in infants with positive results at six weeks of age. We included data for 20 months before and 22 months after the 2010 policy change.
resultsOf the 15,830 HIV tests conducted during our study period, 392 tested positive. We found a significant decrease in both the level (-2.08 positive tests per 100 tests conducted, 95% CI: -2.71 to -1.45, p < 0.001) and trend (-0.11 positive tests per 100 tests conducted per month, 95% CI: -0.16 to -0.07, p < 0.001) of test positivity. This represents an estimated 297 fewer children born without HIV in the post-policy period or a 46% reduction in HIV transmission from mother to child.
conclusionsThe adoption of Option B in Rwanda contributed to an immediate decrease in the rate of HIV transmission from mother to child. This suggests other countries may benefit from adopting these WHO guidelines.
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