SynthesisHuman vaccines & immunotherapeutics2018
Serotype distribution of Streptococcus pneumoniae and potential impact of pneumococcal conjugate vaccines in China: A systematic review and meta-analysis.
Synthesis in Human vaccines & immunotherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Efficacy, immunogenicity, and safety of pneumococcal conjugate vaccine in children: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Prevalence ofHuman vaccines & immunotherapeutics · 2024Pooled it
- Serotype distribution and antimicrobial resistance patterns of invasive pneumococcal disease isolates from children in mainland China-a systematic review.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Pooled it
- Risk factors affecting severe pneumococcal pneumonia in children: a retrospective study.BMC infectious diseases · 2026Article
- Prevalence and serotype distribution of nasopharyngeal carriage ofThe Lancet regional health. Western Pacific · 2026Article
- Genomic analysis of invasive and non-invasive disease-causingMicrobial genomics · 2025Article
- Prevalence of pilus islets and association with clonal complex inMicrobiology spectrum · 2025Article
- Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae in China among children under 14 years of age post-implementation of the PCV13: a systematic review and meta-analysis (2017-2024).Pneumonia (Nathan Qld.) · 2024Review
- Article
- Limited protection of pneumococcal vaccines against emergent Streptococcus pneumoniae serotype 14/ST876 strains.Infection · 2024Article
- [Dose-response relationship between age andZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Effect of pneumococcal conjugate vaccine availability onEmerging microbes & infections · 2022Article
- Comparative Genomic Analysis of Streptococcus pneumoniae Strains: Penicillin Non-susceptible Multi-drug-Resistant Serotype 19A Isolates.Current microbiology · 2022Article
- Genotypic and phenotypic characteristics of Streptococcus pneumoniae from community-acquired pneumonia patients and healthy asymptomatic participants in Sichuan province, China.BMC infectious diseases · 2021Article
- Clinical characteristics and serotype distribution of invasive pneumococcal disease in pediatric patients from Beijing, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Serotype Distribution and Characteristics of the Minimum Inhibitory Concentrations of Streptococcus pneumoniae Isolated from Pediatric Patients in Kunming, China.Current microbiology · 2021Article
- Hospitalization for Invasive Pneumococcal Diseases in Young Children before Use of 13-Valent Pneumococcal Conjugate Vaccine, Suzhou, China.Emerging infectious diseases · 2021Article
- Serotype Distribution, Antimicrobial Susceptibility, Multilocus Sequencing Type and Virulence of InvasiveFrontiers in microbiology · 2021Article
- PspA Diversity, Serotype Distribution and Antimicrobial Resistance of Invasive Pneumococcal Isolates from Paediatric Patients in Shenzhen, China.Infection and drug resistance · 2021Article
- Epidemiology and clinical characteristics of pathogens positive in hospitalized children with segmental/lobar pattern pneumonia.BMC infectious diseases · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThirteen-valent pneumococcal conjugate vaccines (PCV13) was licensed for optional use in mainland China since 2017, but the uptake is low. To update the research evidence for the pneumococcal serotype distribution of pre-PCV era and to estimate the potential impact of PCVs, we performed a meta-analysis on the relevant publications concerning the Chinese population.
methodsThis systematic review and meta-analysis were conducted on the pneumococcal serotype distribution publications in mainland China from 2000 to 2016. The literature was searched in PubMed, Ovid-EMBASE, Web of Science, CNKI and Wanfang. Heterogeneity and publication bias were tested by I
resultsIn total, 85 publications were included. Of all 16,945 included pneumococcal isolates, the most common serotypes/serogroups were 19F, 19A, 23F, 14, and 6B, that from children were the same as above, that from adults≥18 years were 19, 3, 6, 23, and 14. Among isolates from children <18 years, the pooled coverage for PCV10 serotypes was 52.3%, that for PCV13 was 68.4% and that for PPSV23 was 65.5%. Regarding individuals ≥18 years, the pooled coverage for PCV10 serotypes was 29.7%, that for PCV13 was 49.5% and that for PPSV23 was 50.7%. Serotype prevalence and vaccine serotype coverage varied by age group, source, and region.
conclusionsThe most common pneumococcal serotype in mainland China was 19F. The serotype coverage rates of PCV13 and PPSV23 were 50%-68% in mainland China.
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