Evidence map›Paper›PMID 29451783›Full record

ArticleJournal of the American Chemical Society2018

SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization.

Zilei Liu, Jie Li, Suhua Li, Gencheng Li, K Barry Sharpless, Peng Wu

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 301 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Multifunctional Sulfur(VI) Fluoride for SuFEx Reactions: N-CFAngewandte Chemie (International ed. in English) · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Diversity Oriented Clicking for Modular Synthesis.Nature reviews. Methods primers · 2025
    Article
  18. Review
  19. Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zilei LiuDepartment of Molecular Medicine, The Scripps Research Institute , La Jolla, California 92037, United States.ORCID 0000-0002-8749-7595
Jie LiDepartment of Molecular Medicine, The Scripps Research Institute , La Jolla, California 92037, United States.ORCID 0000-0002-8065-5749
Suhua LiDepartment of Chemistry, The Scripps Research Institute , La Jolla, California 92037, United States.
Gencheng LiDepartment of Chemistry, The Scripps Research Institute , La Jolla, California 92037, United States.
K Barry SharplessDepartment of Chemistry, The Scripps Research Institute , La Jolla, California 92037, United States.
Peng WuDepartment of Molecular Medicine, The Scripps Research Institute , La Jolla, California 92037, United States.ORCID 0000-0002-5204-0229
Scripps Research Institute · US

Funding

Sulfur(VI) Fluoride Exchange (SuFEx): new developments and biological applicationsR01GM117145 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SHARPLESS, KARL BARRY · 2016 to 2023
$3.9M
Chemoenzymatic methods for the detection of cellsurface glycansR01GM113046 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI WU, PENG · 2015 to 2018
$1.9M
Chemical tools for studying membrane protein glycosylationR01GM111938 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI OVRYN, BEN, WU, PENG · 2015 to 2018
$1.4M
NIGMS NIH HHS R01 GM111938NIGMS NIH HHS R01 GM113046NIGMS NIH HHS R01 GM117145
6 · The paper itself

Abstract

Sulfur(VI) Fluoride Exchange (SuFEx) is a new family of click chemistry transformations which relies on readily available materials to produce compounds bearing the S

Indexed as

Antineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalClick ChemistryDose-Response Relationship, DrugDrug Resistance, NeoplasmDrug Screening Assays, AntitumorFluoridesHT29 CellsHumansMCF-7 CellsMolecular StructureReceptors, EstrogenStructure-Activity RelationshipSulfurAntineoplastic AgentsFluoridesReceptors, EstrogenSulfur

Identifiers

PMID29451783
PMCPMC6192542
OpenAlexW2786943411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.