Evidence map›Paper›PMID 29451710›Full record

ArticleChemistry & biodiversity2018

Salvisertin A, a New Hexacyclic Triterpenoid, and Other Bioactive Terpenes from Salvia deserta Root.

Yin-Ru Wang, Yun Yu, Shu-Ming Li, Wei Liu, Wei Li, Susan L Morris-Natschke, Masuo Goto, Kuo-Hsiung Lee, Xue-Feng Huang

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Antiprotozoal activity of diterpenoids isolated from Zhumeria majdae- absolute configuration by circular dichroism.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Yin-Ru WangDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, P. R. China.
Yun YuDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, P. R. China.
Shu-Ming LiTasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin, 300410, P. R. China.
Wei LiuNatural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
Wei LiTasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin, 300410, P. R. China.
Susan L Morris-NatschkeNatural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
Masuo GotoNatural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
Kuo-Hsiung LeeNatural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
Xue-Feng HuangDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, P. R. China.
China Pharmaceutical University · CNUniversity of North Carolina at Chapel Hill · USTasly Holding Group (China) · CNNanjing Medical University · CN

Funding

Novel Antitumor AgentsR01CA177584 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEE, KUO-HSIUNG · 2013 to 2017
$1.9M
NCI NIH HHS R01 CA177584
6 · The paper itself

Abstract

Using various chromatographic methods, a new hexacyclic triterpenoid, 2β,3β,24β-trihydroxy-12,13-cyclotaraxer-l4-en-28oic acid (1), together with ten known compounds, 2α,3α,23-trihydroxyurs-12,20(30)-dien-28oic acid (2), 6,7-dehydroroyleanone (3), horminone (4), 7-O-methylhorminone (5), sugiol (6), demethylcryptojaponol (7), 14-deoxycoleon U (8), 5,6-didehydro-7-hydroxy-taxodone (9), ferruginol (10), and dichroanone (11), were isolated from the roots of Salvia deserta. Their structures were identified on the basis of spectroscopic analysis and comparison with the reported data. The individual compounds (1, 3 - 8) were screened for cytotoxic activity, using the sulforhodamine B bioassay (SRB) method. As the results, Compounds 3, 5, and 8 showed cytotoxic potency against A549, MDA-MB-231, KB, KB-VIN, and MCF7 cell lines with IC

Indexed as

Antineoplastic Agents, PhytogenicCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMCF-7 CellsMolecular StructurePlant RootsSalviaStructure-Activity RelationshipTerpenesTriterpenesAntineoplastic Agents, Phytogenicsalvisertin ATerpenesTriterpenescytotoxic activitySalvia desertasalvisertin Astructure elucidationterpenes

Identifiers

PMID29451710
PMCPMC5912963
OpenAlexW2791924200

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.