Evidence map›Paper›PMID 29451704›Full record

ReviewImmunology and cell biology2018

MAIT cells and microbial immunity.

Erin W Meermeier, Melanie J Harriff, Elham Karamooz, David M Lewinsohn

Open access · greenAbstract readReview
In one paragraph

Review in Immunology and cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Mucosal-associated invariant T-cells in pulmonary pathophysiology.Current opinion in pulmonary medicine · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Relevant mechanisms of MAIT cells involved in the pathogenesis of periodontitis.Frontiers in cellular and infection microbiology · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Erin W MeermeierDepartment of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, 97239, USA.ORCID 0000-0002-9709-7624
Melanie J HarriffDepartment of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, 97239, USA.
Elham KaramoozDepartment of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, 97239, USA.
David M LewinsohnDepartment of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, 97239, USA.
Oregon Health & Science University · US

Funding

Multidisciplinary Research Training in Pulmonary MedicineT32HL083808 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., SLATORE, CHRISTOPHER G. · 2008 to 2025
$5.3M
Recognition of Mtb-infected Cells by CD8+ T LymphocytesR01AI048090 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M. · 2001 to 2016
$4.2M
Distinct pathways for MR1 antigen presentation upon infection with intracellular versus extracellular pathogensR01AI129976 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HARRIFF, MELANIE J · 2017 to 2021
$1.9M
Recognition of Mtb-Infected Cells by Non-Classically Restritcted CD8+ T CellsI01BX000533 · VA · PORTLAND VA MEDICAL CENTER · PI LEWINSOHN, DAVID M. · 2011 to 2024
–
Mtb uptake and antigen presentation in human lung epithelial cellsIK2CX000538 · VA · PORTLAND VA MEDICAL CENTER · PI HARRIFF, MELANIE J · 2012 to 2016
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BLRD VA I01 BX000533CSRD VA IK2 CX000538NHLBI NIH HHS T32 HL083808NIAID NIH HHS R01 AI048090NIAID NIH HHS R01 AI129976
6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells, the most abundant T-cell subset in humans, are increasingly being recognized for their importance in microbial immunity. MAIT cells accumulate in almost every mucosal tissue examined, including the lung, liver and intestinal tract, where they can be activated through T-cell receptor (TCR) triggering as well as cytokine stimulation in response to a host of microbial products. In this review, we specifically discuss MAIT cell responses to bacterial and fungal infections, with a focus on responses that are both MR1-dependent and -independent, the evidence for diversity in MAIT TCR usage in response to discrete microbial products, protective immunity induced by MAIT cells, and MAIT cell antimicrobial functions in the context of these infections.

Indexed as

AnimalsBacterial InfectionsHumansImmunity, MucosalMucosal-Associated Invariant T CellsMycosesantimicrobial responsesinfectionMAIT cellsMR1mucosal immunologyunconventional T cells

Identifiers

PMID29451704
PMCPMC6045460
OpenAlexW2793993128

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.