Evidence map›Paper›PMID 29451703›Full record

ArticleBritish journal of pharmacology2018

Mechanisms of imidazoline I

Justin N Siemian, Kaixuan Wang, Yanan Zhang, Jun-Xu Li

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. The imidazoline IPsychopharmacology · 2024
    Article
  3. Article
  4. Article
  5. Evaluating the effects of 2-BFI and tracizoline, two potent INaunyn-Schmiedeberg's archives of pharmacology · 2021
    Article
  6. Article
  7. Observational
  8. Observational
  9. Article
  10. Article
  11. Mechanisms of imidazoline IBritish journal of pharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Justin N SiemianDepartment of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA.
Kaixuan WangDepartment of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA.
Yanan ZhangResearch Triangle Institute, Research Triangle Park, NC, USA.
Jun-Xu LiDepartment of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0003-4749-0767
University at Buffalo, State University of New York · USRTI International · USYantai University · CN

Funding

IMIDAZOLINE I2 RECEPTORS AS TARGETS FOR THE TREATMENT OF PAINR01DA034806 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LI, JUN-XU · 2013 to 2017
$1.7M
NIDA NIH HHS R01 DA034806
6 · The paper itself

Abstract

background and purposeAlthough the antinociceptive efficacies of imidazoline I EXPERIMENTAL APPROACH: von Frey filaments were used to assess antinociceptive effects of two I KEY

resultsIn the CCI model, selective reuptake inhibitors of 5-HT (fluoxetine) or noradrenaline (desipramine), but not dopamine (GBR12909), enhanced 2-BFI-induced antinociception. Selective depletion of 5-HT or noradrenaline almost abolished 2-BFI-induced antinociception. 5-HT CONCLUSIONS AND IMPLICATIONS: Antinociception induced by I

Indexed as

Adrenergic alpha-1 Receptor AntagonistsAnalgesicsAnimalsBiogenic MonoaminesDiscrimination, PsychologicalDrug InteractionsHypothermia, InducedImidazolesImidazoline ReceptorsMaleNeurotransmitter Uptake InhibitorsPain MeasurementQuinazolinesRatsSerotonin AntagonistsSynaptic TransmissionAdrenergic alpha-1 Receptor AntagonistsAnalgesicsBiogenic MonoaminesCR4056Imidazolesimidazoline receptor 2Imidazoline ReceptorsNeurotransmitter Uptake InhibitorsQuinazolinesSerotonin Antagonists

Identifiers

PMID29451703
PMCPMC5900992
OpenAlexW2791019877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.