Evidence map›Paper›PMID 29451491›Full record

ArticleeLife2018

The relationship between spatial configuration and functional connectivity of brain regions.

Janine Diane Bijsterbosch, Mark W Woolrich, Matthew F Glasser, Emma C Robinson, Christian F Beckmann, David C Van Essen, Samuel J Harrison, Stephen M Smith

Registry-linked trialAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 143 papers.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07024875 recruitingnot on this mapstarted 2025, after this paper: background citation

Precision Neuroimaging of Parkinson's Disease

Typeobservational_patient_registrySponsorWashington University School of MedicineRan2025 to 2031Enrolled120ConditionsParkinsons Disease (PD)
3 · Its place in the literature

Who cites it

143 citing papers in PubMed.

  1. Article
  2. Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026
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  11. Review
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  14. Independent Filter Analysis for Group Discrimination in fMRI.bioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
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  18. Article
  19. Action-mode subnetworks for decision-making, action control, and feedback.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Janine Diane BijsterboschCentre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.ORCID http://orcid.org/0000-0002-1385-9178
Mark W WoolrichCentre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
Matthew F GlasserDepartment of Neuroscience, Washington University Medical School, Missouri, United States.
Emma C RobinsonDepartment of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Christian F BeckmannDonders Institute, Radboud University Medical Centre, Nijmegen, Netherlands.
David C Van EssenDepartment of Neuroscience, Washington University Medical School, Missouri, United States.ORCID http://orcid.org/0000-0001-7044-4721
Samuel J Harrison *Centre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-5886-2389
Stephen M Smith *Centre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
NIMH NIH HHS 1U54MH091657NIMH NIH HHS U54 MH091657Wellcome TrustWellcome Trust 091509/Z/10/ZWellcome Trust 098369/Z/12/ZWellcome Trust 203139/Z/16/Z
6 · The paper itself

Abstract

Brain connectivity is often considered in terms of the communication between functionally distinct brain regions. Many studies have investigated the extent to which patterns of coupling strength between multiple neural populations relates to behaviour. For example, studies have used 'functional connectivity fingerprints' to characterise individuals' brain activity. Here, we investigate the extent to which the exact spatial arrangement of cortical regions interacts with measures of brain connectivity. We find that the shape and exact location of brain regions interact strongly with the modelling of brain connectivity, and present evidence that the spatial arrangement of functional regions is strongly predictive of non-imaging measures of behaviour and lifestyle. We believe that, in many cases, cross-subject variations in the spatial configuration of functional brain regions are being interpreted as changes in functional connectivity. Therefore, a better understanding of these effects is important when interpreting the relationship between functional imaging data and cognitive traits.

Indexed as

ConnectomeAdultBehaviorBrainFemaleHumansLife StyleMagnetic Resonance ImagingMaleNeural Pathwaysfingerprintingfunctional connectivityfunctional connectomeshumanneuroscienceparcellationresting state

Identifiers

PMID29451491
PMCPMC5860869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.