Evidence map›Paper›PMID 29451005›Full record

ArticleAIDS care2018

HIV Infection and risk of postpartum infection, complications and mortality in rural Uganda.

Lisa M Bebell, Joseph Ngonzi, Mark J Siedner, Winnie R Muyindike, Bosco M Bwana, Laura E Riley, Yap Boum, David R Bangsberg, Ingrid V Bassett

Open access · greenAbstract read
In one paragraph

Article in AIDS care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Lisa M Bebella Division of Infectious Diseases , Massachusetts General Hospital , Boston , MA , USA.
Joseph Ngonzic Faculty of Medicine , Mbarara University of Science and Technology , Mbarara , Uganda.
Mark J Siednera Division of Infectious Diseases , Massachusetts General Hospital , Boston , MA , USA.
Winnie R Muyindiked Department of Medicine , Mbarara Regional Referral Hospital , Mbarara , Uganda.
Bosco M Bwanac Faculty of Medicine , Mbarara University of Science and Technology , Mbarara , Uganda.
Laura E Rileye Division of Obstetrics and Gynecology , Massachusetts General Hospital , Boston , MA , USA.
Yap Boumc Faculty of Medicine , Mbarara University of Science and Technology , Mbarara , Uganda.
David R Bangsberga Division of Infectious Diseases , Massachusetts General Hospital , Boston , MA , USA.
Ingrid V Bassetta Division of Infectious Diseases , Massachusetts General Hospital , Boston , MA , USA.
Massachusetts General Hospital · USMbarara University of Science and Technology · UGCenter for Global Health · USEpicentre Uganda · UGMbarara National Referral Hospital · UG

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Harvard Clinical and Translational Science CenterKL2TR001100 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$8.5M
Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)R25TW009337 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEIMBURGER, DOUGLAS CORBETT, VERMUND, STEN H. · 2012 to 2016
$6.3M
Behavioral Aspects of Low-cost Medical Devices to Improve HIV CareK23MH099916 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2013 to 2017
$917k
FIC NIH HHS R25 TW009337NCATS NIH HHS KL2 TR001100NIAID NIH HHS L30 AI120147NIAID NIH HHS P30 AI060354NIAID NIH HHS T32 AI007433NIMH NIH HHS K23 MH099916
6 · The paper itself

Abstract

HIV infection may increase risk of postpartum infection and infection-related mortality. We hypothesized that postpartum infection incidence and attributable mortality in Mbarara, Uganda would be higher in HIV-infected than HIV-uninfected women. We performed a prospective cohort study of 4231 women presenting to a regional referral hospital in 2015 for delivery or postpartum care. All febrile or hypothermic women, and a subset of randomly selected normothermic women were followed during hospitalization and with 6-week postpartum phone interviews. The primary outcome was in-hospital postpartum infection. Secondary outcomes included in-hospital complications (mortality, re-operation, intensive care unit transfer, need for imaging or blood transfusion) and 6-week mortality. We performed multivariable regression analyses to estimate adjusted differences in each outcome by HIV serostatus. Mean age was 25.2 years and 481 participants (11%) were HIV-infected. Median CD4+ count was 487 (IQR 325, 696) cells/mm

Indexed as

Maternal MortalityPostpartum PeriodRural PopulationAdultCD4 Lymphocyte CountFemaleHIV InfectionsHospitalizationHumansIncidencePregnancyPregnancy Complications, InfectiousProspective StudiesUgandaYoung AdultAfricaantiretroviralHIVinfectionpregnancypuerperal sepsis

Identifiers

PMID29451005
PMCPMC5980779
OpenAlexW2792055695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.