ArticleStem cells (Dayton, Ohio)2018
Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis.
Article in Stem cells (Dayton, Ohio), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- An integrated multi-tissue approach for endometriosis candidate biomarkers: a systematic review.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Women with endometriosis who undergo IVF: a contemporary review of therapeutic strategies for successful outcomes.Reproductive biology and endocrinology : RB&E · 2025Review
- The role of the CXC chemokine family in endometriosis research and its therapeutic potential.Journal of molecular histology · 2025Review
- Idiopathic Abdominal Wall Endometrioma: Case Report with Investigation of the Pathological, Molecular Cytogenetic and Cell Growth Features In Vitro.International journal of molecular sciences · 2025Article
- Isolated Deep Infiltrating Endometriosis of the Sciatic Nerve: A Case Report and Overview of the Literature.Medicina (Kaunas, Lithuania) · 2023Article
- Endometriosis of the lung: A case report and review of literature.World journal of clinical cases · 2023Article
- Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice.Stem cells international · 2023Article
- Archimetrosis: the evolution of a disease and its extant presentation : Pathogenesis and pathophysiology of archimetrosis (uterine adenomyosis and endometriosis).Archives of gynecology and obstetrics · 2023Article
- Immunopathogenesis of endometriosis - a novel look at an old problem.Central-European journal of immunology · 2022Review
- Polyphenols as a Diet Therapy Concept for Endometriosis-Current Opinion and Future Perspectives.Nutrients · 2021Review
- Menstruation: science and society.American journal of obstetrics and gynecology · 2020Review
- Establishment and Characterization of a Stromal Cell Line Derived From a Patient With Thoracic Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking.Journal of cellular and molecular medicine · 2020Article
- Endometriosis, endocrine disrupters, and epigenetics: an investigation into the complex interplay in women with polybrominated biphenyl exposure and endometriosis.Journal of assisted reproduction and genetics · 2020Article
- The Origin and Pathogenesis of Endometriosis.Annual review of pathology · 2020Review
- Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target.Frontiers in immunology · 2020Review
- Circulating Endometrial Cells: A New Source of Information on Endometriosis Dynamics.Journal of clinical medicine · 2019Article
- Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study.International journal of molecular sciences · 2019Article
- Endometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†.Biology of reproduction · 2019Article
- Anti-inflammatory cytokines in endometriosis.Cellular and molecular life sciences : CMLS · 2019Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Endometriosis is ectopic growth of endometrial tissue traditionally thought to arise through retrograde menstruation. We aimed to determine if cells derived from endometriosis could enter vascular circulation and lead to hematogenous dissemination. Experimental endometriosis was established by transplanting endometrial tissue from DsRed+ mice into the peritoneal cavity of DsRed- mice. Using flow cytometry, we identified DsRed+ cells in blood of animals with endometriosis. The circulating donor cells expressed CXCR4 and mesenchymal stem cell (MSC) biomarkers, but not hematopoietic stem cell markers. Nearly all the circulating endometrial stem cells originated from endometriosis rather than from the uterus. Cells expressing DsRed, CXCR4, and MSCs markers were identified in the peritoneal wall and surrounding vessels of recipient mice, contributing to both endometriosis and angiogenesis. Cells originating in endometriosis lesions migrated and implanted in lung tissue and displayed makers of differentiation, indicating retained multipotency. In vitro these cells demonstrated multipotency and were able to differentiate into adipogenic, osteogenic, and chondrogenic lineages. Endometriosis lesions also expressed high levels of CXCL12, the CXCR4 receptor ligand. Serum CXCL12 levels were greater than in sham control mice. In humans with endometriosis, serum CXCL12 levels were significantly higher than controls, suggesting that the CXCL12/CXCR4 axis is operational in women with spontaneous endometriosis as well. Stem cells, rather than differentiated cells from endometriosis, enter the circulation in response to CXCL12. We identify an endometriosis-derived stem cell population, a potential mechanism of dissemination of this disease and a potential target for treatment of endometriosis. Stem Cells 2018;36:881-890.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.