Evidence map›Paper›PMID 29450895›Full record

Trial reportAlcoholism, clinical and experimental research2018

A Test of Multisession Automatic Action Tendency Retraining to Reduce Alcohol Consumption Among Young Adults in the Context of a Human Laboratory Paradigm.

Robert F Leeman, Christine Nogueira, Reinout W Wiers, Janna Cousijn, Kelly Serafini, Kelly S DeMartini, John A Bargh, Stephanie S O'Malley

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Alcoholism, clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Explicit Attitudes, Working Memory Capacity, and Driving After Drinking.Alcoholism, clinical and experimental research · 2018
    Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Robert F LeemanDepartment of Health Education and Behavior, University of Florida, Gainesville, Florida.ORCID 0000-0002-7003-8907
Christine NogueiraYale School of Medicine, New Haven, Connecticut.
Reinout W WiersDepartment of Psychology, University of Amsterdam, Amsterdam, the Netherlands.
Janna CousijnDepartment of Psychology, University of Amsterdam, Amsterdam, the Netherlands.
Kelly SerafiniSwedish Medical Center, Seattle, Washington.
Kelly S DeMartiniYale School of Medicine, New Haven, Connecticut.ORCID 0000-0003-0943-2507
John A BarghDepartment of Psychology, Yale University, New Haven, Connecticut.
Stephanie S O'MalleyYale School of Medicine, New Haven, Connecticut.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7M
Translational Research of Cocaine, Striatum, and ImpulsivitiesP20DA027844 · NIDA · YALE UNIVERSITY · PI TAYLOR, JANE R · 2010 to 2013
$3.6M
Mediators and Moderators of BSFT for Adolescent Drug UseR01DA017539 · NIDA · UNIVERSITY OF ARIZONA · PI SHOHAM, VARDA · 2003 to 2007
$2.5M
Improving Alcoholism TreatmentK05AA014715 · NIAAA · YALE UNIVERSITY · PI O'MALLEY, STEPHANIE S · 2004 to 2013
$2.1M
Difficulties with Self-Control and High-Risk Alcohol Use in Young AdultsK01AA019694 · NIAAA · YALE UNIVERSITY · PI LEEMAN, ROBERT F · 2010 to 2014
$705k
Testing Automatic Action-Tendency Retraining in Heavy Drinking Young Adults UsingR03AA022232 · NIAAA · YALE UNIVERSITY · PI LEEMAN, ROBERT F · 2013 to 2014
$140k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA019694NIAAA NIH HHS K05 AA014715NIAAA NIH HHS L30 AA016458NIAAA NIH HHS P50 AA012870NIAAA NIH HHS R03 AA022232NIDA NIH HHS P20 DA027844NIDA NIH HHS R01 DA017539
6 · The paper itself

Abstract

backgroundYoung adult heavy drinking is an important public health concern. Current interventions have efficacy but with only modest effects, and thus, novel interventions are needed. In prior studies, heavy drinkers, including young adults, have demonstrated stronger automatically triggered approach tendencies to alcohol-related stimuli than lighter drinkers. Automatic action tendency retraining has been developed to correct this tendency and consequently reduce alcohol consumption. This study is the first to test multiple iterations of automatic action tendency retraining, followed by laboratory alcohol self-administration.

methodsA total of 72 nontreatment-seeking, heavy drinking young adults ages 21 to 25 were randomized to automatic action tendency retraining or a control condition (i.e., "sham training"). Of these, 69 (54% male) completed 4 iterations of retraining or the control condition over 5 days with an alcohol drinking session on Day 5. Self-administration was conducted according to a human laboratory paradigm designed to model individual differences in impaired control (i.e., difficulty adhering to limits on alcohol consumption).

resultsAutomatic action tendency retraining was not associated with greater reduction in alcohol approach tendency or less alcohol self-administration than the control condition. The laboratory paradigm was probably sufficiently sensitive to detect an effect of an experimental manipulation given the range of self-administration behavior observed, both in terms of number of alcoholic and nonalcoholic drinks and measures of drinking topography.

conclusionsAutomatic action tendency retraining was ineffective among heavy drinking young adults without motivation to change their drinking. Details of the retraining procedure may have contributed to the lack of a significant effect. Despite null primary findings, the impaired control laboratory paradigm is a valid laboratory-based measure of young adult alcohol consumption that provides the opportunity to observe drinking topography and self-administration of nonalcoholic beverages (i.e., protective behavioral strategies directly related to alcohol use).

Indexed as

Choice BehaviorAdultAlcohol DrinkingEducationEthanolFemaleHumansMaleSelf AdministrationYoung AdultEthanolAlcohol Self-AdministrationAutomatic Action Tendency RetrainingCognitive Bias RetrainingImpaired Control Over Alcohol UseYoung Adult

Identifiers

PMID29450895
PMCPMC5995797

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.