ArticleThe journal of physiological sciences : JPS2018
Enhancement of pain inhibition by working memory with anodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex.
Article in The journal of physiological sciences : JPS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- The Effects of Transcranial Direct Current Stimulation (tDCS) on the Cognitive Functions: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Identifying regions in prefrontal cortex related to working memory improvement: A novel meta-analytic method using electric field modeling.Neuroscience and biobehavioral reviews · 2021Pooled it
- Does non-invasive brain stimulation modulate emotional stress reactivity?Social cognitive and affective neuroscience · 2020Pooled it
- Independent effects of transcranial direct current stimulation and social influence on pain.Pain · 2025Trial
- Effects of chiropractic spinal manipulation on laser-evoked pain and brain activity.The journal of physiological sciences : JPS · 2021Trial
- Cortical spectral dynamics of vibrotactile frequency processing.Scientific reports · 2025Article
- Chronic pain is specifically associated with updating working memory: a longitudinal twin study.Pain · 2025Article
- Short-term effects of transcranial direct current stimulation on pain sensitivity, emotional and cognitive processes in non-suicidal self-injury: a randomised controlled trial.General psychiatry · 2025Article
- Comparative Neurological and Behavioral Assessment of Central and Peripheral Stimulation Technologies for Induced Pain and Cognitive Tasks.Biomedicines · 2024Article
- Meta-modeling the effects of anodal left prefrontal transcranial direct current stimulation on working memory performance.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Training intervention effects on cognitive performance and neuronal plasticity-A pilot study.Frontiers in neurology · 2022Article
- Pain relief associated with decreased oxyhemoglobin level in left dorsolateral prefrontal cortex.PloS one · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The aim of this study was to examine whether transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) enhances pain inhibition by improving working memory (WM). Forty healthy volunteers participated in two tDCS sessions. Pain was evoked by electrical stimulation at the ankle. Participants performed an n-back task (0-back and 2-back). The experimental protocol comprised five counterbalanced conditions (0-back, 2-back, pain, 0-back with pain and 2-back with pain) that were performed twice (pre-tDCS baseline and during tDCS). Compared with the pre-tDCS baseline values, anodal tDCS decreased response times for the 2-back condition (p < 0.01) but not for the 0-back condition (p > 0.5). Anodal tDCS also decreased pain ratings marginally in the 2-back with pain condition, but not the 0-back with pain condition (p = 0.052 and p > 0.2, respectively). No effect was produced by sham tDCS for any condition (p > 0.2). These results indicate that tDCS of the left DLPFC may enhance pain inhibition by improving WM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.