Evidence map›Paper›PMID 29450738›Full record

Trial reportClinical oral investigations2018

Double-blind, randomized controlled clinical trial on analgesic efficacy of local anesthetics articaine and bupivacaine after impacted third molar extraction.

Maria Victoria Olmedo-Gaya, Francisco Javier Manzano-Moreno, Jose Luis Muñoz-López, Manuel Francisco Vallecillo-Capilla, Candela Reyes-Botella

4 registry-linked trialsOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 4 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04787731 phase4suspendednot on this mapstarted 2019, after this paper: background citation

Efficacy of Two Dental Local Anesthetics on the Oral Health-Related Quality of Life After Endodontic Treatment in the Symptomatic Mandibular Molars: A Double Blind Randomized Controlled Trial

TypeinterventionalSponsorNYU College of DentistryRan2019 to 2024Enrolled100ConditionsPain, Postoperative, Quality of LifeArmsBupivacaine Local Anesthetic
NCT06458478 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effects of the Application of a Hyper-oxygenated Gel After Extraction of Impacted Lower Third Molars: Randomized Controlled Study

TypeinterventionalSponsorAzienda Ospedaliera di PerugiaRan2024 to 2025Enrolled72ConditionsMolar, Fourth, Extracting Own Teeth, Edema Face, PainArmsHyper-oxygenated gel, glycerin based gel
NCT06644950 nacompletednot on this mapstarted 2023, after this paper: background citation

Efficacy and Safety of Administration of Different Doses of 4% Articaine (1:100,000 Epinephrine) Using the Lower Dental Nerve Block Technique for Lower Third Molar Extraction. A Triple-blind Randomized Clinical Trial.

TypeinterventionalSponsorUniversity of BarcelonaRan2023 to 2024Enrolled110ConditionsTooth Extraction Status Nos, Anesthesia, LocalArmsEfficacy and safety of administering 1 or two cartridges of anesthesia
NCT06664060 early_phase1not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Two Nutritional Supplements on Healing and Bone Density in the Jaws

TypeinterventionalSponsorUniversidad de GranadaRan2025 to 2025Enrolled60ConditionsDimensional Changes, Bone DensityArmsosteoimplant, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews.Journal of the American Dental Association (1939) · 2023
    Pooled it
  3. Pooled it
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maria Victoria Olmedo-GayaDepartment of Stomatology, School of Dentistry, University of Granada, Colegio Máximo s/n, 18071, Granada, Spain.
Francisco Javier Manzano-MorenoDepartment of Stomatology, School of Dentistry, University of Granada, Colegio Máximo s/n, 18071, Granada, Spain. fjmanza@ugr.es.ORCID http://orcid.org/0000-0002-3176-7613
Jose Luis Muñoz-LópezMaster of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain.
Manuel Francisco Vallecillo-CapillaDepartment of Stomatology, School of Dentistry, University of Granada, Colegio Máximo s/n, 18071, Granada, Spain.
Candela Reyes-BotellaDepartment of Stomatology, School of Dentistry, University of Granada, Colegio Máximo s/n, 18071, Granada, Spain.
Universidad de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this randomized controlled clinical trial (RCT) was to compare the effect of bupivacaine and articaine at habitual doses on pain intensity and the need for analgesics after lower third molar extraction. MATERIALS AND

methodsThe final study sample comprised 50 Caucasian volunteers (26 males and 24 females; age range, 18-30 years) undergoing scheduled surgical extraction of impacted lower third molar. A computer-generated random sequence was used to allocate participants to the articaine (4%) or bupivacaine (0.5%) group. Surgeons and patients were blinded by labeling the articaine and bupivacaine carpules with numbers (1 and 2, respectively). Postoperative pain intensity (primary outcome) was evaluated with a visual analogue scale (VAS), while the requirement for and timing of rescue medication and the quality of intraoperative anesthesia were also measured (secondary outcomes).

resultsVAS-measured pain intensity was significantly higher (p < 0.05) in the articaine group than in the bupivacaine group at all time points except for 8 h post-surgery (p = 0.052). Rescue medication was required by 13 (52%) patients in the articaine group and 8 (32%) patients in the bupivacaine group, although the difference did not reach statistical significance (p = 0.252). The groups did not significantly differ (p = 0.391) in the quality of the intraoperative anesthesia.

conclusionsBupivacaine is a valid alternative to articaine in third molar surgery and may offer residual anesthesia as a means of reducing postoperative pain. However, further well-designed RCTs are required in larger study populations to verify the effectiveness of bupivacaine to achieve residual analgesia after oral surgery. CLINICAL RELEVANCE: These findings suggest that bupivacaine may be useful as a coadjuvant to control acute postoperative pain.

trial registrationACTRN12617001138370.

Indexed as

Tooth ExtractionAdolescentAdultAnesthetics, LocalBupivacaineCarticaineDouble-Blind MethodFemaleHumansMaleMolar, ThirdPain ManagementPain MeasurementPostoperative PainTooth, ImpactedTreatment OutcomeAnesthetics, LocalBupivacaineCarticaineAcute painArticaineBupivacainePostoperative painThird molar surgery

Identifiers

PMID29450738
OpenAlexW2792410269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.