Evidence map›Paper›PMID 29450729›Full record

ArticleEuropean journal of nutrition2019

Physical activity and Mediterranean diet based on olive tree phenolic compounds from two different geographical areas have protective effects on early osteoarthritis, muscle atrophy and hepatic steatosis.

Marta Anna Szychlinska, Paola Castrogiovanni, Francesca Maria Trovato, Houda Nsir, Mokhtar Zarrouk, Debora Lo Furno, Michelino Di Rosa, Rosa Imbesi, Giuseppe Musumeci

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In one paragraph

Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 4 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 4 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Trial
  6. REJENERAInflammopharmacology · 2026
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  15. Highlights in Pathophysiology of the Musculoskeletal System.International journal of molecular sciences · 2023
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  17. Article
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  19. Review
  20. Clinical features and mechanistic insights into drug repurposing for combating COVID-19.The international journal of biochemistry & cell biology · 2022
    Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Marta Anna SzychlinskaHuman Anatomy and Histology Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 87, 95125, Catania, Italy.
Paola CastrogiovanniHuman Anatomy and Histology Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 87, 95125, Catania, Italy.
Francesca Maria TrovatoDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Houda NsirBiotechnology Laboratory of olive Tree, Centre of Biotechnology of Borj Cedreya, University of Carthage, Carthage, Tunisia.
Mokhtar ZarroukBiotechnology Laboratory of olive Tree, Centre of Biotechnology of Borj Cedreya, University of Carthage, Carthage, Tunisia.
Debora Lo FurnoSection of Physiology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Michelino Di RosaHuman Anatomy and Histology Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 87, 95125, Catania, Italy.
Rosa ImbesiHuman Anatomy and Histology Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 87, 95125, Catania, Italy.
Giuseppe MusumeciHuman Anatomy and Histology Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 87, 95125, Catania, Italy. g.musumeci@unict.it.ORCID http://orcid.org/0000-0002-8260-8890
University of Catania · ITUniversity of Carthage · TN

Funding

Università di Catania University Research Project Grant
6 · The paper itself

Abstract

purposeOsteoarthitis (OA) leads to progressive loss of articular cartilage, pain and joint disability. An acute injury constitutes an important risk factor for early OA, determining an inflammatory process responsible of cartilage degeneration and muscle atrophy, due to the joint pain and immobility. The study aims to assess the effects of conjugation of physical activity and diet enriched by olive tree compounds [extra virgin olive oil (EVOO) and olive leaf extract (OLE)], on the musculoskeletal system in OA rat model.

methodsOA was induced by anterior cruciate ligament transection and confirmed by Mankin and OARSI scores. Rats were subjected to physical activity on treadmill 5 days a week for 10 min daily and fed with experimental diets (standard diet enriched with Sicilian EVOO, Tunisian EVOO and Tunisian EVOO-OLE) for 12 weeks. Immunohistochemistry was used to evaluate IL-6 and lubricin expression in cartilage tissue and ELISA was used to quantify these proteins in serum at different time points. Histology and histomorphometry analysis were done to valuate liver steatosis, muscle atrophy and cartilage pathological changes.

resultsCompared to the OA group, the experimental groups showed general increased lubricin and decreased IL-6 expression, significant muscle hypertrophy and no signs of liver steatosis, suggesting the beneficial effects of physical activity coupled with EVOO-enriched diets on rat articular cartilage. Interestingly, the best result was shown for Sicilian EVOO-enriched diet.

conclusionIn conclusion, the conjugation of physical activity and EVOO-enriched diet determines a significant articular cartilage recovery process in early OA.

Indexed as

Diet, MediterraneanOleaPhysical Conditioning, AnimalAnimalsCartilage, ArticularDisease Models, AnimalFatty LiverMaleMuscular AtrophyOlive OilOsteoarthritisPlant ExtractsRatsRats, WistarOlive OilPlant ExtractsInflammationLubricinMuscle atrophyOlive leaf extractOlive oilOsteoarthritisPhysical activity

Identifiers

PMID29450729
OpenAlexW2788003845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.