ArticleEuropean radiology2018
Could IVIM and ADC help in predicting the KRAS status in patients with rectal cancer?
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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28 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Pretreatment Apparent Diffusion Coefficient Cannot Predict Histopathological Features and Response to Neoadjuvant Radiochemotherapy in Rectal Cancer: A Meta-Analysis.Digestive diseases (Basel, Switzerland) · 2022Pooled it
- Preoperative prediction of KRAS mutation status in colorectal cancer using a CT-based radiomics nomogram.The British journal of radiology · 2022Trial
- Clinical utility and reproducibility of intravoxel incoherent motion MRI in rectal cancer: a structured narrative review.Frontiers in medicine · 2026Review
- Comparison of reduced FOV diffusion-weighted imaging of rectal cancer at 5.0T ultra-high field versus 3.0T MRI: image quality and histopathological T staging.BMC medical imaging · 2025Article
- Non-invasive identification of KRAS mutation in rectal cancer using hybrid intravoxel incoherent motion and diffusion kurtosis model.World journal of surgical oncology · 2025Article
- Intravoxel incoherent motion-derived histogram analysis for quantitative evaluation of tumor budding and prognostic stratification in rectal cancer.European radiology · 2025Article
- Pretreatment intravoxel incoherent motion histogram metrics and clinical characteristics for prediction of perineural invasion status and survival in patients with rectal cancer.Insights into imaging · 2025Article
- Assessment of prognostic indicators and KRAS mutations in rectal cancer using a fractional-order calculus MR diffusion model: whole tumor histogram analysis.Abdominal radiology (New York) · 2025Article
- Prediction of Kirsten rat sarcoma (Quantitative imaging in medicine and surgery · 2024Article
- Significance of apparent diffusion coefficient in diagnosis of rectal carcinoma.Frontiers in oncology · 2024Article
- The Role of Radiomics in Rectal Cancer.Journal of gastrointestinal cancer · 2023Review
- Investigating the Feasibility of Predicting KRAS Status, Tumor Staging, and Extramural Venous Invasion in Colorectal Cancer Using Inter-Platform Magnetic Resonance Imaging Radiomic Features.Diagnostics (Basel, Switzerland) · 2023Article
- Application of intravoxel incoherent motion diffusion-weighted imaging for preoperative knowledge of lymphovascular invasion in gastric cancer: a prospective study.Abdominal radiology (New York) · 2023Article
- Multi-parameter diffusion and perfusion magnetic resonance imaging and radiomics nomogram for preoperative evaluation of aquaporin-1 expression in rectal cancer.Abdominal radiology (New York) · 2022Article
- Role of MRI‑based radiomics in locally advanced rectal cancer (Review).Oncology reports · 2022Review
- Emerging applications of radiomics in rectal cancer: State of the art and future perspectives.World journal of gastroenterology · 2021Review
- Radiogenomics in Colorectal Cancer.Cancers · 2021Review
- The value of bi-exponential and non-Gaussian distribution diffusion-weighted imaging in the differentiation of recurrent soft tissue neoplasms and post-surgical changes.Annals of translational medicine · 2020Article
- Development and validation of a MRI-based radiomics signature for prediction of KRAS mutation in rectal cancer.European radiology · 2020Article
- T stage prediction of colorectal tumor based on multiparametric functional images.Translational cancer research · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the diagnostic potential of DW-MRI relative parameters for differentiation of rectal cancers with different Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation status.
methodsFifty-one patients with rectal cancer underwent diffusion-weighted MR imaging with eight b values. ADCs (including Max-ADC, Min-ADC and Mean-ADC) and IVIM parameters (D, pure diffusion; f, perfusion fraction; D*, pseudodiffusion coefficient) were respectively calculated by mono- and bi-exponential analysis. Patients were stratified into two groups: KRAS wild type and mutant. The DW-MRI-derived parameters between the KRAS wild-type group and KRAS mutant group were compared using the Mann-Whitney U test. Receiver-operating characteristic (ROC) analysis of discrimination between KRAS wild-type and KRAS mutant rectal cancer was performed for the DW-MRI-derived parameters.
resultsMax-ADC, Mean-ADC and D values were significantly lower in the KRAS mutant group than in the KRAS wild-type group, whereas a higher D* value was demonstrated in the KRAS mutant group. According to the ROC curve, Mean-ADC and D* values showed moderate diagnostic significance with the AUC values of 0.756 and 0.710, respectively. The cut-off values for Mean-ADC and D* were 1.43 × 10
conclusionRectal cancers had distinctive diffusion/perfusion characteristics in different KRAS mutation statuses. The DW-MRI-derived parameters, specifically Mean-ADC and D*, show a moderate diagnostic significance for KRAS status. KEY POINTS: • Rectal cancers with different KRAS mutation statuses demonstrated distinctive diffusion/perfusion characteristics. • Max-ADC, Mean-ADC and D values were lower in the KRAS mutant group. • A higher D* value was demonstrated in the KRAS mutant group. • IVIM-DW MRI may potentially help preoperative KRAS mutant status prediction.
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