Evidence map›Paper›PMID 29450576›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2018

ImmunoPET imaging of CD38 in murine lymphoma models using

Lei Kang, Dawei Jiang, Christopher G England, Todd E Barnhart, Bo Yu, Zachary T Rosenkrans, Rongfu Wang, Jonathan W Engle, Xiaojie Xu, Peng Huang and 1 more

2 registry-linked trialsAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06385652 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Clinical PET Imaging Evaluation of 68Ga-NB381 Probe in Multiple Myeloma

TypeinterventionalSponsorPeking University First HospitalRan2024 to 2026Enrolled30ConditionsMultiple MyelomaArms68Ga-NB381
NCT06717113 early_phase1recruitingnot on this mapstarted 2025, after this paper: background citation

Clinical PET Imaging Evaluation of 68Ga-BC1 Probe in Multiple Myeloma

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2028Enrolled50ConditionsMultiple Myeloma and Malignant Plasma Cell NeoplasmsArms18F-FDG, 68Ga-BC1
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. PET Imaging of CD38 and IND enabling studies of [Molecular imaging and biology · 2026
    Article
  3. Article
  4. Article
  5. [American journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Article
  7. Article
  8. Theranostic role ofEuropean journal of nuclear medicine and molecular imaging · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. European journal of nuclear medicine and molecular imaging · 2022
    Article
  13. CD38-specific nanobodies allowFrontiers in immunology · 2022
    Article
  14. Article
  15. ImmunoPET imaging of multiple myeloma with [European journal of nuclear medicine and molecular imaging · 2021
    Article
  16. Article
  17. CD38-Targeted Theranostics of Lymphoma withAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  18. Development of [European journal of nuclear medicine and molecular imaging · 2021
    Article
  19. Noninvasive Evaluation of CD20 Expression UsingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  20. Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Lei KangDepartment of Nuclear Medicine, Peking University First Hospital, Beijing, 100034, China.
Dawei JiangDepartment of Radiology, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Christopher G EnglandDepartment of Medical Physics, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Bo YuDepartment of Radiology, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Zachary T RosenkransSchool of Pharmacy, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Rongfu WangDepartment of Nuclear Medicine, Peking University First Hospital, Beijing, 100034, China.
Jonathan W EngleDepartment of Medical Physics, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Xiaojie XuDepartment of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, 100850, China. miraclexxj@126.com.
Peng HuangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Nanhai Ave 3688, Shenzhen, 518060, China. peng.huang@szu.edu.cn.
Weibo CaiDepartment of Radiology, University of Wisconsin - Madison, Madison, WI, 53705, USA. wcai@uwhealth.org.ORCID 0000-0003-4641-0833
University of Wisconsin–Madison · USBeijing National Laboratory for Molecular Sciences · CNPeking University · CNShenzhen University · CN

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Membranous Nanogenerators for in vivo Bio-mechanical Energy HarvestingR01EB021336 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, XUDONG · 2016 to 2020
$1.7M
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
American Cancer Society 125246-RSG-13-099-01-CCEBasic Research Program of Shenzhen JCYJ20160422091238319Basic Research Program of Shenzhen JCYJ20170412111100742Beijing Capital Special Development Application Program Z141107002514159Beijing Nova Program Z171100001117024National Natural Science Foundation of China 51573096National Natural Science Foundation of China 81401465National Natural Science Foundation of China 81441051NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NCI NIH HHS T32 CA009206NIBIB NIH HHS 1R01CA169365NIBIB NIH HHS R01 EB021336NIH HHS 1R01EB021336NIH HHS P30CA014520NIH HHS T32CA009206
6 · The paper itself

Abstract

purposeCD38 is considered a potential biomarker for multiple myeloma (MM) and has shown a strong link with chronic lymphocytic leukemia due to high and uniform expression on plasma cells. In vivo evaluation of CD38 expression may provide useful information about lesion detection and prognosis of treatment in MM. In this study, immunoPET imaging with

methodsDaratumumab was radiolabeled with

resultsUsing WB screening, the Ramos cell line was found to express the highest level of CD38 while the HBL-1 cell line had the lowest expression. Df-conjugated and

conclusionsThe role of

Indexed as

ADP-ribosyl Cyclase 1AnimalsAntibodies, MonoclonalCell Line, TumorLymphomaMiceMice, NudePositron-Emission TomographyRadioisotopesTissue DistributionZirconiumADP-ribosyl Cyclase 1Antibodies, MonoclonaldaratumumabRadioisotopesZirconiumZirconium-8989ZrB-cell lymphomaCancerCD38DaratumumabImmunoPETPositron emission tomography (PET)

Identifiers

PMID29450576
PMCPMC5994170
OpenAlexW2793394424

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.