ArticleThyroid research2018
Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases.
Article in Thyroid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 2 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- Pooled it
- Autoimmune thyroiditis and comorbid autoimmune diseases: global research landscape and future directions.Frontiers in immunology · 2026Pooled it
- Intrathyroid injection of dexamethasone inhibits Th2 cells in Graves' disease.Archives of endocrinology and metabolismTrial
- Different clinical autoimmune polyglandular syndrome phenotypes among patients with thyroid diseases.Journal of endocrinological investigation · 2026Article
- Inverse association between peripheral natural killer cells and thyroid autoimmunity in cases of miscarriage: Evidence from a cross-sectional study.The Journal of international medical research · 2026Article
- Inflammatory protein expression patterns in Hashimoto's thyroiditis: a cross-sectional observational study.Clinical proteomics · 2026Article
- Association Between Albumin-to-Globulin Ratio and Hashimoto's Thyroiditis: A Cross-Sectional Study Based on NHANES 2007-2012.International journal of endocrinology · 2026Article
- Taming autoimmune thyroiditis: cellular immunomodulation through MSCs, Tregs, and tolDCs.Frontiers in immunology · 2026Review
- Intraocular inflammation after intravitreal injection of faricimab-a case series including one case of bilateral choroidal involvement.International journal of ophthalmology · 2026Article
- The role of hypothyroidism in cirrhosis pathogenesis: A retrospective cohort study and multi-omics integration analysis.PLoS genetics · 2025Article
- Pathogenic genes associated with immune-related genes in graves' disease: a multi-omics Mendelian randomization analysis.Scientific reports · 2025Article
- Autoimmune Thyroid Diseases and Physical Activity and Sports-More Unknowns than Facts.Biomedicines · 2025Review
- Dupilumab-Induced Graves' Disease in an Adult With Chronic Rhinosinusitis and Nasal Polyposis.Cureus · 2025Article
- Machine learning in lymphocyte and immune biomarker analysis for childhood thyroid diseases in China.BMC pediatrics · 2025Article
- Application of Thyroid Hormones in Women's Hair for the Non-Invasive Prediction of Graves' Disease.Biomolecules · 2025Article
- Iodine activates NLRP3 inflammasomes in PBMCs of patients with autoimmune thyroiditis and regulates Th1 and Th17 cell differentiation.Endocrine connections · 2025Article
- Exploring the comorbidity mechanisms between atherosclerosis and hashimoto's thyroiditis based on microarray and single-cell sequencing analysis.Scientific reports · 2025Article
- Endocrine polyautoimmunity: Mechanistic insights and the future of AI-driven diagnostics.EXCLI journal · 2025Review
- The diverseFrontiers in immunology · 2025Article
- Persistent symptoms in euthyroid Hashimoto's thyroiditis: current hypotheses and emerging management strategies.Frontiers in endocrinology · 2025Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune thyroid disorders (AITD) broadly include Graves' disease and Hashimoto's thyroiditis which are the most common causes of thyroid gland dysfunctions. These disorders develop due to complex interactions between environmental and genetic factors and are characterized by reactivity to self-thyroid antigens due to autoreactive lymphocytes escaping tolerance. Both cell-mediated and humoral responses lead to tissue injury in autoimmune thyroid disease. The differentiation of CD4+ cells in the specific setting of immune mediators (for example cytokines, chemokines) results in differentiation of various T cell subsets. T cell identification has shown a mixed pattern of cytokine production indicating that both subtypes of T helper, Th1 and Th2, responses are involved in all types of AITD. Furthermore, recent studies described T cell subtypes Th17 and Treg which also play an essential role in pathogenesis of AITD. This review will focus on the role of the T regulatory (Treg) and T helper (Th) (especially Th17) lymphocytes, and also of B lymphocytes in AITD pathogenesis. However, we have much more to learn about cellular mechanisms and interactions in AITD before we can develop complete understanding of AITD pathophysiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.