ArticleBiotechnology for biofuels2018
Mathematical models of lignin biosynthesis.
Article in Biotechnology for biofuels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 62 citations in OpenAlex.
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- Format-Preserving Reduction of Canonical Nonlinear Models.Bulletin of mathematical biology · 2026Article
- A Guide to Metabolic Network Modeling for Plant Biology.Plants (Basel, Switzerland) · 2025Review
- Chemical Synthesis of Monolignols: Traditional Methods, Recent Advances, and Future Challenges in Sustainable Processes.Antioxidants (Basel, Switzerland) · 2024Review
- Model-assisted analysis for tuning anthocyanin composition in grape berries.Annals of botany · 2023Article
- Comparative transcriptome and co-expression network analysis revealed the genes associated with senescence and polygalacturonase activity involved in pod shattering of rapeseed.Biotechnology for biofuels and bioproducts · 2023Article
- Identification and analysis of lignin biosynthesis genes related to fruit ripening and stress response in banana (Frontiers in plant science · 2023Article
- Developmental changes in lignin composition are driven by both monolignol supply and laccase specificity.Science advances · 2022Article
- Genome-Wide Identification and Characterization ofPlants (Basel, Switzerland) · 2021Article
- Systematic Analysis and Biochemical Characterization of the Caffeoyl Shikimate Esterase Gene Family in Poplar.International journal of molecular sciences · 2021Article
- Enzyme Complexes of Ptr4CL and PtrHCT Modulate Co-enzyme A Ligation of Hydroxycinnamic Acids for Monolignol Biosynthesis inFrontiers in plant science · 2021Article
- Phenylalanine and Tyrosine as Exogenous Precursors of Wheat (Plants (Basel, Switzerland) · 2020Article
- Lignin biosynthesis: old roads revisited and new roads explored.Open biology · 2019Review
- Article
- EGTA reduces the inflorescence stem mechanical strength of herbaceous peony by modifying secondary wall biosynthesis.Horticulture research · 2019Article
- Enzyme-Enzyme Interactions in Monolignol Biosynthesis.Frontiers in plant science · 2018Review
- A dynamic model of lignin biosynthesis inBiotechnology for biofuels · 2018Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLignin is a natural polymer that is interwoven with cellulose and hemicellulose within plant cell walls. Due to this molecular arrangement, lignin is a major contributor to the recalcitrance of plant materials with respect to the extraction of sugars and their fermentation into ethanol, butanol, and other potential bioenergy crops. The lignin biosynthetic pathway is similar, but not identical in different plant species. It is in each case comprised of a moderate number of enzymatic steps, but its responses to manipulations, such as gene knock-downs, are complicated by the fact that several of the key enzymes are involved in several reaction steps. This feature poses a challenge to bioenergy production, as it renders it difficult to select the most promising combinations of genetic manipulations for the optimization of lignin composition and amount.
resultsHere, we present several computational models than can aid in the analysis of data characterizing lignin biosynthesis. While minimizing technical details, we focus on the questions of what types of data are particularly useful for modeling and what genuine benefits the biofuel researcher may gain from the resulting models. We demonstrate our analysis with mathematical models for black cottonwood (
conclusionsDespite commonality in pathway structure, different plant species show different regulatory features and distinct spatial and topological characteristics. The putative lignin biosynthes pathway is not able to explain the plant specific laboratory data, and the necessity of plant specific modeling should be heeded.
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