Evidence map›Paper›PMID 29449867›Full record

ReviewNutrition & metabolism2018

Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D.

Shahida Khan, Ashraf Ali, Sarah Khan, Ahmed Bakillah, Ghazi Damanhouri, Aziz Khan, Ahmad Makki, Ibtehal AlAnsari, Naheed Banu

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Nutrition & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Shahida Khan1Applied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz University, P.O.Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.
Ashraf Ali1Applied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz University, P.O.Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.
Sarah Khan2National Brain Research Center, Manesar, Gurgaon, 122051 India.
Ahmed Bakillah3Department of Medicine, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203 USA.
Ghazi Damanhouri1Applied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz University, P.O.Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.
Aziz Khan1Applied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz University, P.O.Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.
Ahmad Makki1Applied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz University, P.O.Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.
Ibtehal AlAnsari1Applied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz University, P.O.Box 80216, Jeddah, 21589 Kingdom of Saudi Arabia.
Naheed Banu4Department of Biochemistry, College of Medical Rehabilitation, Buraydah, Qassim University, P.O. Box 51452, Qassim, Kingdom of Saudi Arabia.
King Abdulaziz University · SANational Brain Research Centre · INQassim University · SASUNY Downstate Health Sciences University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Liver dysfunction is a topic of global concern with many advancing therapies being researched. Though vitamin D takes a center place, other therapies especially nutritional are also gaining ground. Vitamin D has gone beyond its role in skeletal disorders by showcasing its associations in other metabolic dysfunctions too. Result: Epidemiological evidences show a correlation between the status of vitamin D and different forms of cancer. Vitamin D receptors and alterations in gene expression appear decisive in the development of chronic liver disorders. Nutritional status therefore plays a significant role in avoiding the complications related to liver dysfunctions, making it mandatory in maintaining vitamin D sufficiency in the body. Therapies with omega-3 fatty acids, antioxidants, amino acids, steroids also render benefits which could be further explored. Recent research on the progression of certain forms of liver cancer using vitamin D analogs like Seocalcitol EB 1089 has shown good promise. Conclusion: The anti-inflammatory and immuno- regulatory properties of vitamin D makes its analogs, suitable candidates of better choice for the prevention and treatment of liver disorders and cancer.

Indexed as

Anti-inflammatoryCurrent therapiesLiver disordersVitamin D

Identifiers

PMID29449867
PMCPMC5807831
OpenAlexW2789786642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.