Evidence map›Paper›PMID 29449845›Full record

ReviewFrontiers in immunology2018

Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.

Juan Tang, Guoxin Lin, Wallace Y Langdon, Lijian Tao, Jian Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 105 citations in OpenAlex.

  1. Review
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  10. A promisingClinical and experimental vaccine research · 2025
    Review
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  12. Association of myeloid cell reactivity patterns with safe food predictions in FPIES patients.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025
    Article
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Juan TangDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Guoxin LinDepartment of Pathology, The University of Iowa, Iowa City, IA, United States.
Wallace Y LangdonSchool of Biological Sciences, University of Western Australia, Perth, WA, Australia.
Lijian TaoDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jian ZhangDepartment of Pathology, The University of Iowa, Iowa City, IA, United States.
Xiangya Hospital Central South University · CNThird Xiangya Hospital · CNUniversity of Iowa · USUniversity of Western Australia · AU

Funding

NEDD4 IN T HELPER CELL DEVELOPMENT AND AUTOIMMUNITYR01AI090901 · NIAID · UNIVERSITY OF IOWA · PI WALDSCHMIDT, THOMAS J · 2010 to 2020
$4.0M
Regulation of Innate Immune System Sensing of C. Albicans InfectionsR01AI123253 · NIAID · UNIVERSITY OF IOWA · PI WALDSCHMIDT, THOMAS J · 2016 to 2020
$2.1M
Role of Protein Ubiquitination in SepsisR01AI121196 · NIAID · UNIVERSITY OF IOWA · PI ZHANG, JIAN · 2016 to 2020
$1.7M
NIAID NIH HHS R01 AI090901NIAID NIH HHS R01 AI121196NIAID NIH HHS R01 AI123253
6 · The paper itself

Abstract

Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system.

Indexed as

AnimalsHumansInflammasomesLectins, C-TypeMycosesProtein Processing, Post-TranslationalInflammasomesLectins, C-TypeC-type lectin receptorfungal infectionimmunityposttranslational modificationssignaling pathways

Identifiers

PMID29449845
PMCPMC5799234
OpenAlexW2794422589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.