Evidence map›Paper›PMID 29449839›Full record

ArticleFrontiers in immunology2017

Long-term Maintenance of CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected with

Kirsten E Lyke, Abdoulaye Dabo, Charles Arama, Issa Diarra, Christopher V Plowe, Ogobara K Doumbo, Marcelo B Sztein

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Immunosuppression in Malaria: DoPathogens (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Kirsten E LykeCenter for Vaccine Development, Institute for Global Health, School of Medicine, University of Maryland, Baltimore, MD, United States.
Abdoulaye DaboMalaria Research and Training Center, International Centers for Excellence in Research (NIH), University of Science Techniques and Technologies of Bamako, Bamako, Mali.
Charles AramaMalaria Research and Training Center, International Centers for Excellence in Research (NIH), University of Science Techniques and Technologies of Bamako, Bamako, Mali.
Issa DiarraMalaria Research and Training Center, International Centers for Excellence in Research (NIH), University of Science Techniques and Technologies of Bamako, Bamako, Mali.
Christopher V PloweCenter for Vaccine Development, Institute for Global Health, School of Medicine, University of Maryland, Baltimore, MD, United States.
Ogobara K DoumboMalaria Research and Training Center, International Centers for Excellence in Research (NIH), University of Science Techniques and Technologies of Bamako, Bamako, Mali.
Marcelo B SzteinCenter for Vaccine Development, Institute for Global Health, School of Medicine, University of Maryland, Baltimore, MD, United States.
Université des Sciences, des Techniques et des Technologies de Bamako · MLUniversity of Maryland, Baltimore · US

Funding

Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RASKO, DAVID A · 2014 to 2023
$36.5M
Clinical trial of trimethoprim-sulfamethoxazole or chloroquine in adults on ARTU01AI089342 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LAUFER, MIRIAM K. · 2011 to 2017
$13.7M
Genetic diversity and protective immunity to malaria infection and diseaseU01AI065683 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PLOWE, CHRISTOPHER V. · 2010 to 2014
$3.0M
Malaria:Clinical Research and Trial Preparation Sites-26685346N01AI085346 · NIAID · Univ Maryland · 1998 to 2004
$2.8M
Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in HumansR01AI067954 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LYKE, KIRSTEN E · 2008 to 2011
$1.1M
A Systems Biology Approach to Malaria ImmunityR01AI110852 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI WILLIAMSON, KIM C · 2015 to 2015
$778k
NIAID NIH HHS HHSN272201000049INIAID NIH HHS N01 AI085346NIAID NIH HHS R01 AI067954NIAID NIH HHS R01 AI110852NIAID NIH HHS U01 AI065683NIAID NIH HHS U01 AI089342NIAID NIH HHS U19 AI110820
6 · The paper itself

Abstract

Polyparasitism is common in the developing world. We have previously demonstrated that schistosomiasis-positive (SP) Malian children, aged 4-8 years, are protected from malaria compared to matched schistosomiasis-negative (SN) children. The effect of concomitant schistosomiasis upon acquisition of T cell memory is unknown. We examined antigen-specific T cell frequencies in 48 Malian children aged 4-14 to a pool of malaria blood stage antigens, and a pool of schistosomal antigens, at a time point during a malaria episode and at a convalescent time point ~6 months later, following cessation of malaria transmission. CD4

Indexed as

coinfectionmalariamemorymultifunctional T cellsPlasmodium falciparumschistosomiasisT cell memory

Identifiers

PMID29449839
PMCPMC5799235
OpenAlexW2791607195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.