Evidence map›Paper›PMID 29449712›Full record

ReviewNature reviews. Neuroscience2018

Imaging structural and functional brain development in early childhood.

John H Gilmore, Rebecca C Knickmeyer, Wei Gao

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 551 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
551citing papers in PubMed, 3 pooled it
32.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

551 citing papers in PubMed, 3 syntheses or guidelines pooled it, 992 citations in OpenAlex.

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491 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

John H GilmoreDepartment of Psychiatry, CB# 7160, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Rebecca C KnickmeyerDepartment of Psychiatry, CB# 7160, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Wei GaoBiomedical Imaging Research Institute, Department of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
University of North Carolina at Chapel Hill · USCedars-Sinai Medical Center · US

Funding

Preclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN · 2013 to 2019
$8.0M
Early Brain Development in TwinsR01MH070890 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2004 to 2014
$5.3M
Early Brain Development in One and Two Year OldsR01HD053000 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2007 to 2018
$4.4M
The Origins of Preadolescent Risk for Psychiatric Disorders in Early Childhood Brain DevelopmentR01MH111944 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2017 to 2021
$3.5M
Early Brain Development in TwinsU01MH070890 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2015 to 2019
$2.9M
Genome-wide Identification of Variants Affecting Early Human Brain DevelopmentR01MH092335 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNICKMEYER, REBECCA · 2011 to 2015
$2.5M
GUT MICROBIOTA AND ANXIETY: A MECHANISTIC STUDY OF HUMAN INFANTSR33MH104330 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNICKMEYER, REBECCA, STYNER, MARTIN ANDREAS · 2016 to 2018
$2.1M
GUT MICROBIOTA AND ANXIETY: A MECHANISTIC STUDY OF HUMAN INFANTSR21MH104330 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNICKMEYER, REBECCA · 2014 to 2015
$504k
Functional Dissection of Prenatal Drug Effects on the Developing Brain and BehaviorR21DA043171 · NIDA · CEDARS-SINAI MEDICAL CENTER · PI GAO, WEI, GREWEN, KAREN M · 2017 to 2018
$474k
Creating Normative Functional Brain Atlases During InfancyR21NS088975 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI GAO, WEI, LIN, WEILI · 2015 to 2016
$447k
Prenatal cocaine exposure and functional connectivity in early infancyR03DA036645 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GAO, WEI, GREWEN, KAREN M · 2014 to 2014
$228k
NICHD NIH HHS R01 HD053000NICHD NIH HHS U54 HD079124NIDA NIH HHS R03 DA036645NIDA NIH HHS R21 DA043171NIMH NIH HHS R01 MH070890NIMH NIH HHS R01 MH092335NIMH NIH HHS R01 MH111944NIMH NIH HHS R21 MH104330NIMH NIH HHS R33 MH104330NIMH NIH HHS U01 MH070890NINDS NIH HHS R21 NS088975
6 · The paper itself

Abstract

In humans, the period from term birth to ∼2 years of age is characterized by rapid and dynamic brain development and plays an important role in cognitive development and risk of disorders such as autism and schizophrenia. Recent imaging studies have begun to delineate the growth trajectories of brain structure and function in the first years after birth and their relationship to cognition and risk of neuropsychiatric disorders. This Review discusses the development of grey and white matter and structural and functional networks, as well as genetic and environmental influences on early-childhood brain development. We also discuss initial evidence regarding the usefulness of early imaging biomarkers for predicting cognitive outcomes and risk of neuropsychiatric disorders.

Indexed as

BiomarkersBrainChild DevelopmentCognitionGene-Environment InteractionGray MatterHumansInfantInfant, NewbornMental DisordersNeural PathwaysNeuroimagingRisk FactorsWhite MatterBiomarkers

Identifiers

PMID29449712
PMCPMC5987539
OpenAlexW2788755901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.