ArticleHypertension research : official journal of the Japanese Society of Hypertension2018
Pre-pregnancy endothelial dysfunction and birth outcomes: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 18 citations in OpenAlex.
- Adverse pregnancy outcomes and long-term risk of peripheral artery disease: A cohort study.PLoS medicine · 2026Article
- Adverse Pregnancy Outcomes and Long-Term Risk of Atrial Fibrillation.JAMA cardiology · 2025Article
- Adverse pregnancy outcomes and long-term risk of stroke: a Swedish nationwide co-sibling study.European heart journal · 2025Article
- Adverse Pregnancy Outcomes and Long-Term Risk of Heart Failure in Women: National Cohort and Co-Sibling Study.JACC. Heart failure · 2025Article
- Inflammatory, metabolic, and endothelial biomarkers before and after pregnancy complications.American journal of epidemiology · 2024Article
- Adverse pregnancy outcomes and long-term risk of chronic kidney disease in women: national cohort and co-sibling study.American journal of obstetrics and gynecology · 2024Article
- Women's Reproductive Milestones and Cardiovascular Disease Risk: A Review of Reports and Opportunities From the CARDIA Study.Journal of the American Heart Association · 2023Review
- Adverse pregnancy outcomes and long term risk of ischemic heart disease in mothers: national cohort and co-sibling study.BMJ (Clinical research ed.) · 2023Article
- Retinal vessel diameters, flicker-induced retinal vasodilation and retinal oxygen saturation in high- and low-risk pregnancy.Acta ophthalmologica · 2021Article
- Preterm Delivery and Long-Term Risk of Stroke in Women: A National Cohort and Cosibling Study.Circulation · 2021Article
- Effects of miR‑195‑5p on cell proliferation and apoptosis in gestational diabetes mellitus via targeting EZH2.Molecular medicine reports · 2020Article
- Pre-Term Delivery and Risk of Ischemic Heart Disease in Women.Journal of the American College of Cardiology · 2020Article
- Association of circulating saturated fatty acids with the risk of pregnancy-induced hypertension: a nested case-control study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Associations of systolic blood pressure trajectories during pregnancy and risk of adverse perinatal outcomes.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
Endothelial dysfunction is a form of subclinical cardiovascular disease that may be involved in preterm birth and small-for-gestational-age deliveries. However, concentrations of biomarkers of endothelial dysfunction before pregnancy have rarely been measured. We hypothesized that higher levels of biomarkers of endothelial dysfunction (cellular adhesion molecules and selectins) would be associated with odds of preterm birth and/or small-for-gestational-age deliveries. We included 235 women from the Coronary Artery Risk Development in Young Adults (CARDIA) study who were nulliparous at Y7, reported ≥1 live birth through Y25, and had ≥1 biomarker measured at Y7. We tested for associations between individual biomarkers and an averaged z-score representing total endothelial dysfunction with preterm birth and/or small-for-gestational-age deliveries using Poisson regression, adjusted for demographic and clinical characteristics at the exam immediately preceding index birth. At Y7, total evidence of endothelial dysfunction was similar in women who did (n = 59) and did not have (n = 176) preterm birth and/or small-for-gestational-age deliveries. There was no association between biomarkers of endothelial dysfunction (either individual biomarker or total score) with odds of preterm birth and/or small-for-gestational-age deliveries after adjustment: IRR = 1.01, 95% CI: 0.74, 1.39, p = 0.93 for total endothelial biomarker score. Associations were not modified by race. We conclude that biomarkers of endothelial dysfunction in nulliparous women, measured ~3 years before pregnancy, did not identify women at risk for preterm birth and/or small-for-gestational-age deliveries. This suggests that the maternal endothelial dysfunction that is believed to contribute to these birth outcomes may not be detectable before pregnancy.
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