Evidence map›Paper›PMID 29449589›Full record

ArticleScientific reports2018

Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model.

Apoorva Mulay, Derek W Hood, Debbie Williams, Catherine Russell, Steve D M Brown, Lynne Bingle, Michael Cheeseman, Colin D Bingle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Panel 1: Biotechnology, biomedical engineering and new models of otitis media.International journal of pediatric otorhinolaryngology · 2020
    Review
  3. Panel 3: Genomics, precision medicine and targeted therapies.International journal of pediatric otorhinolaryngology · 2020
    Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Apoorva MulayAcademic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Derek W HoodMRC Mammalian Genetics Unit, MRC Harwell Institute, Didcot, UK.
Debbie WilliamsMRC Mammalian Genetics Unit, MRC Harwell Institute, Didcot, UK.
Catherine RussellAcademic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Steve D M BrownMRC Mammalian Genetics Unit, MRC Harwell Institute, Didcot, UK.
Lynne BingleOral and Maxillofacial Pathology, Department of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Michael CheesemanRoslin Institute, University of Edinburgh, Edinburgh, UK.
Colin D BingleAcademic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK. c.d.bingle@sheffield.ac.uk.ORCID 0000-0002-5405-6988
University of Sheffield · GBMary Lyon Centre at MRC Harwell · GBRoslin Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/K009737/1Medical Research Council MC_U142684175Medical Research Council MC_UP_1503/1
6 · The paper itself

Abstract

Otitis Media (OM) is characterized by epithelial abnormalities and defects in innate immunity in the middle ear (ME). Although, BPIFA1, a member of the BPI fold containing family of putative innate defence proteins is abundantly expressed by the ME epithelium and SNPs in Bpifa1 have been associated with OM susceptibility, its role in the ME is not well characterized. We investigated the role of BPIFA1 in protection of the ME and the development of OM using murine models. Loss of Bpifa1 did not lead to OM development. However, deletion of Bpifa1 in Evi1

Indexed as

AnimalsDisease Models, AnimalEar, MiddleEpitheliumFemaleGene ExpressionGenes, RegulatorGlycoproteinsInflammationMaleMiceMice, Inbred C57BLMice, KnockoutOtitis MediaPhosphoproteinsProteostasisBpifa1 protein, mouseGlycoproteinsPhosphoproteins

Identifiers

PMID29449589
PMCPMC5814562
OpenAlexW2803520858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.