Evidence map›Paper›PMID 29449453›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

Conserved and Divergent Features of Human and Mouse Kidney Organogenesis.

Nils O Lindström, Jill A McMahon, Jinjin Guo, Tracy Tran, Qiuyu Guo, Elisabeth Rutledge, Riana K Parvez, Gohar Saribekyan, Robert E Schuler, Christopher Liao and 8 more

Abstract readComparative Study
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Dissecting Normal and Abnormal Human Kidney Development Using Multiomics.Journal of the American Society of Nephrology : JASN · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Spatial and Temporal Expression Patterns of EDA2R, PCDH9, and TRAF7 inInternational journal of molecular sciences · 2025
    Article
  17. Article
  18. Cross-Species Data Integration for Enhanced Layer Segmentation in Kidney Pathology.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  19. Review
  20. Review

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Nils O LindströmDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Jill A McMahonDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Jinjin GuoDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Tracy TranDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Qiuyu GuoDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Elisabeth RutledgeDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Riana K ParvezDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Gohar SaribekyanDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Robert E SchulerInformation Sciences Institute, Viterbi School of Engineering.
Christopher LiaoDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Albert D KimDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Ahmed AbdelhalimDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Seth W RuffinsDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine.
Matthew E ThorntonMaternal Fetal Medicine Division, University of Southern California, Los Angeles, California; and.
Laurence BaskinDepartment of Urology and Pediatrics, University of California San Francisco, San Francisco, California.
Brendan GrubbsMaternal Fetal Medicine Division, University of Southern California, Los Angeles, California; and.
Carl KesselmanInformation Sciences Institute, Viterbi School of Engineering.
Andrew P McMahonDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, amcmahon@med.usc.edu.

Funding

The USC (Re)Building the Kidney Coordinating CenterU01DK107350 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KESSELMAN, CARL, VALERIUS, MICHAEL TODD · 2015 to 2019
$9.0M
Training in Developmental Biology, Stem Cells and RegenerationT32HD060549 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Gage D Crump · 2011 to 2026
$2.5M
GUDMAP2 - Production of Mouse Strains for Gene Anatomy of the Lower Urinary TractU01DK094526 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCMAHON, ANDREW P. · 2011 to 2015
$2.5M
Four-dimensional Modeling of Mouse and Human Nephrogenesis.U01DK110792 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCMAHON, ANDREW P. · 2016 to 2020
$1.9M
Characterization of in vivo and in vitro nephrogenesisF32DK109616 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KIM, ALBERT D · 2016 to 2018
$174k
Characterizing Novel Regulators of Branching Morphogenesis within the Ureteric Bud TipF31DK107216 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RUTLEDGE, ELISABETH · 2015 to 2017
$112k
Medical Research Council G0700089NICHD NIH HHS T32 HD060549NIDDK NIH HHS F31 DK107216NIDDK NIH HHS F32 DK109616NIDDK NIH HHS U01 DK094526NIDDK NIH HHS U01 DK107350NIDDK NIH HHS U01 DK110792Wellcome Trust
6 · The paper itself

Abstract

Human kidney function is underpinned by approximately 1,000,000 nephrons, although the number varies substantially, and low nephron number is linked to disease. Human kidney development initiates around 4 weeks of gestation and ends around 34-37 weeks of gestation. Over this period, a reiterative inductive process establishes the nephron complement. Studies have provided insightful anatomic descriptions of human kidney development, but the limited histologic views are not readily accessible to a broad audience. In this first paper in a series providing comprehensive insight into human kidney formation, we examined human kidney development in 135 anonymously donated human kidney specimens. We documented kidney development at a macroscopic and cellular level through histologic analysis, RNA

Indexed as

OrganogenesisAnimalsCell DifferentiationFluorescent Antibody TechniqueGene Expression ProfilingGestational AgeHistological TechniquesHumansIn Situ HybridizationKidneyMiceNephronsRNAUreterRNAhuman geneticskidney developmentnephron

Identifiers

PMID29449453
PMCPMC5827606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.