Evidence map›Paper›PMID 29449426›Full record

ArticleThe European respiratory journal2018

DNA methylation modules in airway smooth muscle are associated with asthma severity.

Mark M Perry, Paul Lavender, Chih-Hsi Scott Kuo, Francesca Galea, Charalambos Michaeloudes, James M Flanagan, Kian Fan Chung, Ian M Adcock

Abstract readLetter
In one paragraph

Article in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Aberrant Methylation of Aging-Related Genes in Asthma.Frontiers in molecular biosciences · 2021
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mark M PerrySchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
Paul LavenderMRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Kings College London, London, UK.
Chih-Hsi Scott KuoDiscovery Science Group, Dept of Computing, Imperial College London, London, UK.
Francesca GaleaEpigenetics Unit, Dept of Surgery and Cancer, Imperial College London, London, UK.
Charalambos MichaeloudesAirways Disease, National Heart and Lung Institute, Imperial College, London and Royal Brompton NIHR Biomedical Research Unit, London, UK.
James M FlanaganAirways Disease, National Heart and Lung Institute, Imperial College, London and Royal Brompton NIHR Biomedical Research Unit, London, UK.
Kian Fan ChungAirways Disease, National Heart and Lung Institute, Imperial College, London and Royal Brompton NIHR Biomedical Research Unit, London, UK.
Ian M AdcockAirways Disease, National Heart and Lung Institute, Imperial College, London and Royal Brompton NIHR Biomedical Research Unit, London, UK.

Funding

Medical Research Council G1000758Wellcome Trust 085935
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationAdultAnimalsAsthmaCpG IslandsFemaleGene ExpressionGenome-Wide Association StudyHumansMaleMiddle AgedMyocytes, Smooth MusclePhenotypeRespiratory SystemYoung Adult

Identifiers

PMID29449426
PMCPMC5902304

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.