Evidence map›Paper›PMID 29449365›Full record

ArticleGenes & development2018

'Big bang' of B-cell development revealed.

Cornelis Murre

Abstract readComment
In one paragraph

Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Epigenetic Priming in Immunodeficiencies.Frontiers in cell and developmental biology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Cornelis MurreDepartment of Molecular Biology, University of California at San Diego, La Jolla, California 92093, USA.

Funding

The role of TCR, ligand, and signal strength in human γδ T cell developmentP01AI102853 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI CORNELIS MURRE · 2014 to 2026
$26.3M
E-proteins and EBF1 in B cell differentiationR01AI109599 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MURRE, CORNELIS · 2014 to 2017
$1.6M
NIAID NIH HHS P01 AI102853NIAID NIH HHS R01 AI109599
6 · The paper itself

Abstract

Earlier studies have identified transcription factors that specify B-cell fate, but the underlying mechanisms remain to be revealed. Two new studies by Miyai and colleagues (pp. 112-126) and Li and colleagues (pp. 96-111) in this issue of

Indexed as

Trans-ActivatorsB-LymphocytesCell DifferentiationLymphocyte ActivationTranscription FactorsTrans-ActivatorsTranscription FactorsB-cell differentiationB-cell programmingchromatinEBF1epigeneticsIRF4Pax5transcription factor

Identifiers

PMID29449365
PMCPMC5830931

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.