ArticleArteriosclerosis, thrombosis, and vascular biology2018
RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells From Inflammation and Attenuates Atherosclerosis.
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
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23 citing papers in PubMed, 40 citations in OpenAlex.
- The Role of miRNA-146a and Proinflammatory Cytokines in Carotid Atherosclerosis.BioMed research international · 2020Trial
- Computational Investigation of Smooth Muscle Cell Plasticity in Atherosclerosis and Vascular Calcification: Insights from Differential Gene Expression Analysis of Microarray Data.Bioengineering (Basel, Switzerland) · 2025Article
- Behavior of Complement System Effectors in Chronic and Acute Coronary Artery Disease.Journal of clinical medicine · 2025Article
- Pulsatile low shear stress increases susceptibility to endothelial inflammation via upregulation of IFT and activation of YAP.APL bioengineering · 2025Article
- The Interplay Between Immunity, Inflammation and Endothelial Dysfunction.International journal of molecular sciences · 2025Review
- Inhibiting MiR-33a-3p Expression Fails to Enhance ApoAI-Mediated Cholesterol Efflux in Pro-Inflammatory Endothelial Cells.Medicina (Kaunas, Lithuania) · 2025Article
- Multi-Omics Analysis Combined with Machine Learning Identified FABP4 in Smooth Muscle Cells as a Pathogenic Factor in Atherosclerosis.Journal of inflammation research · 2025Article
- An novel effective and safe model for the diagnosis of nonalcoholic fatty liver disease in China: gene excavations, clinical validations, and mechanism elucidation.Journal of translational medicine · 2024Article
- Abnormal expression of PRKAG2-AS1 in endothelial cells induced inflammation and apoptosis by reducing PRKAG2 expression.Non-coding RNA research · 2024Article
- DOCK2 Promotes Atherosclerosis by Mediating the Endothelial Cell Inflammatory Response.The American journal of pathology · 2024Article
- The Impact of MiR-33a-5p Inhibition in Pro-Inflammatory Endothelial Cells.Diseases (Basel, Switzerland) · 2023Article
- Vulnerable Atherosclerotic Plaque: Is There a Molecular Signature?International journal of molecular sciences · 2022Review
- SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment.International journal of biological sciences · 2022Article
- Single-cell RNA sequencing in vision research: Insights into human retinal health and disease.Progress in retinal and eye research · 2021Review
- Vascular Endothelial Cells and Innate Immunity.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Annual Report on Sex in Preclinical Studies:Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Molecular mechanism for the multiple sclerosis risk variant rs17594362.Human molecular genetics · 2019Article
- RGC-32 and diseases: the first 20 years.Immunologic research · 2019Review
- Updates on Approaches for Studying Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Response Gene to Complement 32 Maintains Blood Pressure Homeostasis by Regulating α-Adrenergic Receptor Expression.Circulation research · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Xiao-Bing CuiFrom the Department of Physiology and Pharmacology (X.-B.C., J.-N.L., K.D., S.C., S.-Y.C.) and Department of Infectious Diseases (W.T.W.), University of Georgia, Athens; Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, China (S.C., S.-Y.C.); and Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China (Y.W.).
Jun-Na LuanFrom the Department of Physiology and Pharmacology (X.-B.C., J.-N.L., K.D., S.C., S.-Y.C.) and Department of Infectious Diseases (W.T.W.), University of Georgia, Athens; Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, China (S.C., S.-Y.C.); and Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China (Y.W.).
Kun DongFrom the Department of Physiology and Pharmacology (X.-B.C., J.-N.L., K.D., S.C., S.-Y.C.) and Department of Infectious Diseases (W.T.W.), University of Georgia, Athens; Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, China (S.C., S.-Y.C.); and Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China (Y.W.).
Sisi ChenFrom the Department of Physiology and Pharmacology (X.-B.C., J.-N.L., K.D., S.C., S.-Y.C.) and Department of Infectious Diseases (W.T.W.), University of Georgia, Athens; Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, China (S.C., S.-Y.C.); and Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China (Y.W.).
Yongyi WangFrom the Department of Physiology and Pharmacology (X.-B.C., J.-N.L., K.D., S.C., S.-Y.C.) and Department of Infectious Diseases (W.T.W.), University of Georgia, Athens; Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, China (S.C., S.-Y.C.); and Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China (Y.W.).
Wendy T WatfordFrom the Department of Physiology and Pharmacology (X.-B.C., J.-N.L., K.D., S.C., S.-Y.C.) and Department of Infectious Diseases (W.T.W.), University of Georgia, Athens; Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, China (S.C., S.-Y.C.); and Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China (Y.W.).
Shi-You ChenFrom the Department of Physiology and Pharmacology (X.-B.C., J.-N.L., K.D., S.C., S.-Y.C.) and Department of Infectious Diseases (W.T.W.), University of Georgia, Athens; Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, China (S.C., S.-Y.C.); and Department of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China (Y.W.). sc229@uga.edu.
Hubei University of Medicine · CN
Funding
Novel mechanism of smooth muscle phenotypic modulation and vascular remodelingR01HL119053 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2014 to 2023
$3.8MSmad2 in vascular smooth muscle homeostasisR01HL135854 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2017 to 2020
$2.0MDedicator of Cytokinesis 2 in smooth muscle phenotype modulationR01HL123302 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2014 to 2018
$1.8MAmerican Heart Association-American Stroke Association 17SDG32790003NHLBI NIH HHS R01 HL119053NHLBI NIH HHS R01 HL123302NHLBI NIH HHS R01 HL135854
Abstract
objectiveThe objective of this study is to determine the role and underlying mechanisms of RGC-32 (response gene to complement 32 protein) in atherogenesis. APPROACH AND
resultsRGC-32 was mainly expressed in endothelial cells of atherosclerotic lesions in both ApoE
conclusionsRGC-32 mediates atherogenesis by facilitating monocyte-endothelial cell interaction via the induction of endothelial ICAM-1 and VCAM-1 expression, at least partially, through NF-κB signaling pathway.
Indexed as
AnimalsAtherosclerosisCell AdhesionCell Cycle ProteinsCoculture TechniquesDisease Models, AnimalEndothelial CellsGenetic Predisposition to DiseaseHumansHuman Umbilical Vein Endothelial CellsInflammationInflammation MediatorsIntercellular Adhesion Molecule-1MacrophagesMaleMice, Inbred C57BLCell Cycle ProteinsIcam1 protein, mouseInflammation MediatorsIntercellular Adhesion Molecule-1Muscle ProteinsNerve Tissue ProteinsNF-kappa BNuclear ProteinsRgc-32 protein, mouseRGCC protein, humanVascular Cell Adhesion Molecule-1animalsatherosclerosisendothelial cellshumansmice
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.