Evidence map›Paper›PMID 29449314›Full record

ReviewEndocrine connections2018

Vitamin D, PCOS and androgens in men: a systematic review.

Christian Trummer, Stefan Pilz, Verena Schwetz, Barbara Obermayer-Pietsch, Elisabeth Lerchbaum

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Endocrine connections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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  9. Vitamin D and polycystic ovary syndrome (PCOS): a review.Annals of medicine and surgery (2012) · 2023
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  12. Oxidative Stress, Testosterone, Cortisol, and Vitamin D: Differences in Professional Soccer Players of African and Caucasian Origin.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christian TrummerDepartment of Internal MedicineDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Stefan PilzDepartment of Internal MedicineDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Verena SchwetzDepartment of Internal MedicineDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Barbara Obermayer-PietschDepartment of Internal MedicineDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Elisabeth LerchbaumDepartment of Internal MedicineDivision of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria elisabeth.lerchbaum@medunigraz.at.
Medical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the reproductive system in both genders.

aimThe aim of this review was to provide an overview on the effects of vitamin D on polycystic ovary syndrome (PCOS) in women and androgen metabolism in men.

methodsWe performed a systematic literature search in PubMed for relevant English language publications published from January 2012 until September 2017. RESULTS AND DISCUSSION: The vitamin D receptor and vitamin D-metabolizing enzymes are found in reproductive tissues of women and men. In women, vitamin D status has been associated with several features of PCOS. In detail, cross-sectional data suggest a regulatory role of vitamin D in PCOS-related aspects such as ovulatory dysfunction, insulin resistance as well as hyperandrogenism. Moreover, results from randomized controlled trials (RCTs) suggest that vitamin D supplementation may be beneficial for metabolic, endocrine and fertility aspects in PCOS. In men, vitamin D status has been associated with androgen levels and hypogonadism. Further, there is some evidence for a favorable effect of vitamin D supplementation on testosterone concentrations, although others failed to show a significant effect on testosterone levels.

conclusionIn summary, vitamin D deficiency is associated with adverse fertility outcomes including PCOS and hypogonadism, but the evidence is insufficient to establish causality. High-quality RCTs are needed to further evaluate the effects of vitamin D supplementation in PCOS women as well as on androgen levels in men.

Indexed as

polycystic ovary syndromerandomized controlled trialsystematic reviewtestosteronevitamin D

Identifiers

PMID29449314
PMCPMC5854850
OpenAlexW2788914315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.