Evidence map›Paper›PMID 29449280›Full record

ArticleAJNR. American journal of neuroradiology2018

Prediction of the Multisegment Clot Sign on Dynamic CT Angiography of Cardioembolic Stroke.

Z Chen, F Shi, M Zhang, X Gong, L Lin, M Lou

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Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Z ChenFrom the Department of Neurology (Z.C., F.S., M.Z., X.G., M.L.), the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.ORCID 0000-0003-4937-6749
F ShiFrom the Department of Neurology (Z.C., F.S., M.Z., X.G., M.L.), the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.ORCID 0000-0001-9855-5765
M ZhangFrom the Department of Neurology (Z.C., F.S., M.Z., X.G., M.L.), the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.ORCID 0000-0002-9588-2733
X GongFrom the Department of Neurology (Z.C., F.S., M.Z., X.G., M.L.), the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.ORCID 0000-0002-0047-1246
L LinSchool of Medicine and Public Health (L.L.), University of Newcastle, New South Wales, Australia.ORCID 0000-0001-7104-9846
M LouFrom the Department of Neurology (Z.C., F.S., M.Z., X.G., M.L.), the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China lm99@zju.edu.cn.ORCID 0000-0002-6627-064X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe multisegment clot sign has been observed at the site of large-artery occlusion in patients with acute ischemic stroke. This study aimed to assess its occurrence rate and relationship with stroke etiologies in patients with acute intracranial large-artery occlusion. MATERIALS AND

methodsWe included consecutive patients with acute ischemic stroke who had acute intracranial large-artery occlusion and underwent perfusion CT within 8 hours after stroke onset. The multisegment clot sign was assessed on dynamic CT angiography derived from perfusion CT. The stroke etiologies were defined by the international Trial of Org 10172 in Acute Stroke Treatment criteria. Poisson regression analyses and diagnostic testing were used to investigate the relationship between the multisegment clot sign and stroke etiologies.

resultsFinally, 194 patients with intracranial large-artery occlusion were enrolled. According to the Trial of Org 10172 in Acute Stroke Treatment criteria, 110 (56.7%) patients were diagnosed with cardioembolism; 43 (22.2%), with large-artery atherosclerosis; and 41 (21.1%), with undetermined etiology. The multisegment clot sign was found in 74 (38%) patients. Poisson regression analysis showed that the presence of the multisegment clot sign was significantly higher in patients with cardioembolism than in those with large-artery atherosclerosis (52.7% versus 9.3%; prevalence ratio, 1.53; 95% confidence interval, 1.03-2.90;

conclusionsThe presence of the multisegment clot sign on dynamic CTA specifically indicates intracranial large-artery occlusion caused by an embolism from a cardiac source, which may be useful for acute management and secondary prevention of stroke.

Indexed as

AgedAged, 80 and overCerebral AngiographyComputed Tomography AngiographyFemaleHumansMaleMiddle AgedRegression AnalysisSensitivity and SpecificityStrokeThromboembolism

Identifiers

PMID29449280
PMCPMC7410775

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.