BMI and outcomes in melanoma: more evidence for the obesity paradox.

Andrew J Hayes, James Larkin

Abstract readComment

In one paragraph

Article in The Lancet. Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it

0cells of the map it votes in

9citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

Obesity and melanoma: unraveling the paradoxical survival benefit in immunotherapy.Cancer metastasis reviews · 2026
Review
Adipose-Derived Exosomes: mediators of crosstalk between Adipose tissue and cancer.Cancer biology & therapy · 2025
Review
Association of body fat percentage with diabetes in hypertensive adults of different genders: a cross-sectional study.Frontiers in endocrinology · 2025
Article
Impact of obesity‑associated myeloid‑derived suppressor cells on cancer risk and progression (Review).International journal of oncology · 2024
Review
Leptin, Both Bad and Good Actor in Cancer.Biomolecules · 2021
Review
Exosome miR-27a-3p secreted from adipocytes targets ICOS to promote antitumor immunity in lung adenocarcinoma.Thoracic cancer · 2020
Article
Body surface area, height, and body fat percentage as more sensitive risk factors of cancer and cardiovascular disease.Cancer medicine · 2020
Article
The Role of Autophagy in Liver Epithelial Cells and Its Impact on Systemic Homeostasis.Nutrients · 2019
Review
Obesity and Breast Cancer: Role of Leptin.Frontiers in oncology · 2019
Review

4 · The record

Corrections and comments

Comment on
Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis.2018

5 · Who and what money

Authors and funding

2 authors.

Andrew J HayesDepartment of Surgery, Melanoma Unit, Royal Marsden NHS Trust, London SW3 6JJ, UK. Electronic address: andrew.hayes@rmh.nhs.uk.

James LarkinDepartment of Medical Oncology, Melanoma Unit, Royal Marsden NHS Trust, London SW3 6JJ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Body Mass IndexObesityHumansImmunotherapyMelanomaRetrospective Studies

Identifiers

PMID29449191

DOI10.1016/S1470-2045(18)30077-9

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.