ReviewClinical biomechanics (Bristol, Avon)2019
Biomechanical simulation of traumatic brain injury in the rat.
Review in Clinical biomechanics (Bristol, Avon), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Investigation of quantitative structural changes in astrocyte cells after laser-induced shockwave.Biophotonics discovery · 2025Article
- An Air-Filled Bicycle Helmet for Mitigating Traumatic Brain Injury.Bioengineering (Basel, Switzerland) · 2023Article
- "The Most Gentle of Lethal Methods": The Question of Retained Consciousness Following Decapitation.Cureus · 2023Review
- Cranial Bone Changes Induced by Mild Traumatic Brain Injuries: A Neglected Player in Concussion Outcomes?Neurotrauma reports · 2023Article
- Inhibition of PDE10A-Rescued TBI-Induced Neuroinflammation and Apoptosis through the cAMP/PKA/NLRP3 Pathway.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Evidence of early vasogenic edema following minor head impact that can be reduced with a vasopressin V1a receptor antagonist.Brain research bulletin · 2020Article
- A machine learning approach for magnetic resonance image-based mouse brain modeling and fast computation in controlled cortical impact.Medical & biological engineering & computing · 2020Article
- Improved voiding function by deep brain stimulation in traumatic brain-injured animals with bladder dysfunctions.International urology and nephrology · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
backgroundTraumatic brain injury poses an enormous clinical challenge. Rats are the animals most widely used in pre-clinical experiments. Biomechanical simulations of these experiments predict the distribution of mechanical stress and strain across key tissues. It is in theory possible to dramatically increase our understanding of traumatic brain injury pathophysiology by correlating stress and strain with histological and functional injury outcomes. This review summarizes the state of the art in biomechanical simulation of traumatic brain injury in the rat. It also places this body of knowledge in the context of the wider effort to understand traumatic brain injury in rats and in humans.
methodsPeer-reviewed research articles on biomechanical simulation of traumatic brain injury in the rat were reviewed and summarized.
findingsWhen mathematical models of traumatic brain injury in the rat first emerged, they relied on scant data regarding biomechanical properties. The data on relevant biomechanical properties has increased recently. However, experimental models of traumatic brain injury in the rat have also become less homogeneous. New and modified models have emerged that are biomechanically distinct from traditional models.
interpretationImportant progress in mathematical modeling and measurement of biomechanical properties has led to credible, predictive simulations of traditional, experimental models of traumatic brain injury in the rat, such as controlled cortical impact. However, recent trends such as the increasing popularity of closed head models and blast models create new biomechanical challenges. Investigators studying rat brain biomechanics must continue to innovate to keep pace with these developments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.