Observational studySeminars in arthritis and rheumatism2018
Periarticular bone predicts knee osteoarthritis progression: Data from the Osteoarthritis Initiative.
Observational study in Seminars in arthritis and rheumatism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Effect of high-intensity training on improving knee flexion strength and quality of life in patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2025Pooled it
- Defining and predicting radiographic knee osteoarthritis progression: a systematic review of findings from the osteoarthritis initiative.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Pooled it
- Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index.International journal of epidemiology · 2022Pooled it
- Persistent bone and muscle deficits after anterior cruciate ligament reconstruction : implications for post-traumatic osteoarthritis risk.Bone & joint research · 2026Article
- Subchondral bone density and trabecular morphometry mediate the association between knee malalignment and osteophyte progression in osteoarthritis: data from the osteoarthritis initiative.Clinical rheumatology · 2026Article
- Relationship between knee pain and depth-specific measures of proximal tibial subchondral bone density.Osteoarthritis and cartilage · 2025Article
- Study on Bone Mineral Density Around the Knee in Postmenopausal Women with Osteoarthritis and Osteoporosis.International journal of women's health · 2025Article
- Short-term variations in trabecular bone texture parameters associated to radio-clinical biomarkers improve the prediction of radiographic knee osteoarthritis progression.Scientific reports · 2023Article
- Subchondral bone in knee osteoarthritis: bystander or treatment target?Skeletal radiology · 2023Review
- Bone mineral density around the knee after open wedge high tibial osteotomy measured up to 24 months in 51 patients.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Radiographic Biomarkers for Knee Osteoarthritis: A Narrative Review.Life (Basel, Switzerland) · 2023Review
- Conventional MRI-derived subchondral trabecular biomarkers and their association with knee cartilage volume loss as early as 1 year: a longitudinal analysis from Osteoarthritis Initiative.Skeletal radiology · 2022Article
- Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample.Arthritis research & therapy · 2022Article
- Quantifying the Human Subchondral Trabecular Bone Microstructure in Osteoarthritis with Clinical CT.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Epidemiology of osteoarthritis.Osteoarthritis and cartilage · 2022Review
- Association between current medication use and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative.Rheumatology (Oxford, England) · 2021Observational
- Osteoporosis is associated with varus deformity in postmenopausal women with knee osteoarthritis: a cross-sectional study.BMC musculoskeletal disorders · 2021Article
- Trabecular bone texture analysis of conventional radiographs in the assessment of knee osteoarthritis: review and viewpoint.Arthritis research & therapy · 2021Review
- Bisphosphonates, Bone and Joint Pain.Current osteoporosis reports · 2021Review
- Conventional MRI-based subchondral trabecular biomarkers as predictors of knee osteoarthritis progression: data from the Osteoarthritis Initiative.European radiology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 10 institutions in 2 countries.
Funding
Abstract
objectiveOsteoarthritis (OA) is a disease with a substantial public health burden. Quantitative assessments of periarticular bone may be a biomarker capable of monitoring early disease progression. The purpose of this study was to evaluate whether measures of periarticular bone associate with longitudinal structural progression.
methodsWe conducted a 12-18 months longitudinal study using the Osteoarthritis Initiative (OAI). Participants received knee dual-energy x-ray absorptiometry (DXA), trabecular magnetic resonance (MR) imaging, and x-rays. Knee DXAs generated proximal tibial medial:lateral periarticular bone mineral density (paBMD) measures. Proximal tibial trabecular MR images were assessed for trabecular morphometry: apparent bone volume fraction (BVF), trabecular number, thickness, and spacing. Weight-bearing x-rays were assessed for medial tibiofemoral joint space narrowing (JSN). Chi-squared analyses assessed whether periarticular bone measures were predictive of worsening medial tibiofemoral JSN, adjusted for age, sex, and BMI.
resultsIn all, 444 participants, mean age 64.2 ± 9.2 years, BMI 29.5 ± 4.6kg/m
conclusionBaseline and most rates of periarticular bone change associate with knee OA structural progression, highlighting the close relationship between subchondral bone and JSN. Future studies should focus on developing these measures as predictive and pathophysiological biomarkers, and evaluating their deployment in clinical trials testing bone-targeted therapeutics.
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Registered trials
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