Evidence map›Paper›PMID 29448926›Full record

Trial reportBMC pediatrics2018

Histologic chorioamnionitis in preterm infants: correlation with brain magnetic resonance imaging at term equivalent age.

Claire Granger, Alicia J Spittle, Jennifer Walsh, Jan Pyman, Peter J Anderson, Deanne K Thompson, Katherine J Lee, Lee Coleman, Charuta Dagia, Lex W Doyle and 1 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Claire GrangerDepartment of Neonatal Medicine, Royal Children's Hospital, Melbourne, Australia. cmacgilchrist@doctors.org.uk.
Alicia J SpittleVictorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia.
Jennifer WalshVictorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia.
Jan PymanDepartment of Pathology, Royal Women's Hospital, Melbourne, Australia.
Peter J AndersonVictorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia.
Deanne K ThompsonVictorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia.
Katherine J LeeDepartment of Paediatrics, University of Melbourne, Melbourne, Australia.
Lee ColemanDepartment of Paediatrics, University of Melbourne, Melbourne, Australia.
Charuta DagiaDepartment of Paediatrics, University of Melbourne, Melbourne, Australia.
Lex W DoyleVictorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia.
Jeanie CheongVictorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, Australia.
University of Melbourne · AURoyal Women's Hospital · AURoyal Children's Hospital · AUMonash University · AUMurdoch Children's Research Institute · AU

Funding

Australia National Health and Medical Research Council 1028822 & 1024516Australian National Health and Medical Research Counci 1053787Australian National Health and Medical Research Council 1053609Australian National Health and Medical Research Council 1060733Australian National Health and Medical Research Council 1081288Australian National Health and Medical Research Council 1085754Australian National Health and Medical Research Council 1108714
6 · The paper itself

Abstract

backgroundTo explore the associations between histologic chorioamnionitis with brain injury, maturation and size on magnetic resonance imaging (MRI) of preterm infants at term equivalent age.

methodsPreterm infants (23-36 weeks' gestational age) were recruited into two longitudinal cohort studies. Presence or absence of chorioamnionitis was obtained from placental histology and clinical data were recorded. MRI at term-equivalent age was assessed for brain injury (intraventricular haemorrhage, cysts, signal abnormalities), maturation (degree of myelination, gyral maturation) and size of cerebral structures (metrics and brain segmentation). Histologic chorioamnionitis was assessed as a predictor of MRI variables using linear and logistic regression, with adjustment for confounding perinatal variables.

resultsTwo hundred and twelve infants were included in this study, 47 (22%) of whom had histologic chorioamnionitis. Histologic chorioamnionitis was associated with higher odds of intraventricular haemorrhage (odds ratio [OR] (95% confidence interval [CI]) = 7.4 (2.4, 23.1)), less mature gyral maturation (OR (95% CI) = 2.0 (1.0, 3.8)) and larger brain volume (mean difference in cubic centimeter (95% CI) of 14.1 (1.9, 26.2)); but all relationships disappeared following adjustment for perinatal variables.

conclusionHistologic chorioamnionitis was not independently associated with IVH, less mature gyral maturation or brain volume at term-equivalent age in preterm infants.

Indexed as

Magnetic Resonance ImagingBrainBrain InjuriesChorioamnionitisFemaleHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesLinear ModelsLogistic ModelsLongitudinal StudiesMalePregnancyProspective StudiesRisk FactorsBrain volumesChorioamnionitisIntraventricular haemorrhageMagnetic resonance imagingPreterm

Identifiers

PMID29448926
PMCPMC5815189
OpenAlexW2795661300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.