Evidence map›Paper›PMID 29448295›Full record

Trial reportThrombosis and haemostasis2018

Recombinant FXIII (rFXIII-A2) Prophylaxis Prevents Bleeding and Allows for Surgery in Patients with Congenital FXIII A-Subunit Deficiency.

Manuel Carcao, Carmen Altisent, Giancarlo Castaman, Katsuyuki Fukutake, Bryce A Kerlin, Craig Kessler, Riitta Lassila, Diane Nugent, Johannes Oldenburg, May-Lill Garly and 2 more

Abstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Thrombosis and haemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Rare inherited coagulation disorders: no longer orphan and neglected.Research and practice in thrombosis and haemostasis · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Safety and effectiveness of recombinant factor XIII-AResearch and practice in thrombosis and haemostasis · 2022
    Article
  8. Factor XIII-A: An Indispensable "Factor" in Haemostasis and Wound Healing.International journal of molecular sciences · 2021
    Review
  9. [Hereditary coagulation factor XIII deficiency: three cases report and literaure review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Manuel CarcaoDivision of Haematology/Oncology and Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada.
Carmen AltisentHaemophilia Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
Giancarlo CastamanDepartment of Oncology, Careggi University Hospital, Center for Bleeding Disorders and Coagulation, Firenze, Italy.
Katsuyuki FukutakeDepartment of Laboratory Medicine, Tokyo Medical University, Tokyo, Japan.
Bryce A KerlinOhio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio, United States.
Craig KesslerGeorgetown University Medical Center, Washington, DC, United States.
Riitta LassilaCoagulation Disorders Unit, Hematology and Comprehensive Cancer Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Diane NugentCenter for Inherited Blood Disorders and UC Irvine Medical School, Children's Hospital of Orange County, Orange, California, United States.
Johannes OldenburgInstitute for Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany.
May-Lill GarlyMedical & Science, Biopharm, Global Development, Novo Nordisk A/S, Søborg, Denmark.
Anders RosholmBiostatistics, Biopharm, Global Development, Novo Nordisk A/S, Søborg, Denmark.
Aida InbalSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recombinant factor XIII-A

Indexed as

Surgical Procedures, OperativeAdolescentAdultAgedChildFactor VIIIaFactor XIII DeficiencyFemaleHemorrhageHemostasisHumansMaleMiddle AgedPatient SafetyRecombinant ProteinsYoung AdultFactor VIIIaRecombinant Proteins

Identifiers

PMID29448295
PMCPMC6260112

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.