ArticleDevelopmental cognitive neuroscience2018
Hubs in the human fetal brain network.
Article in Developmental cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Functional brain growth trajectories across the first decade of life from a single longitudinal cohort.Research square · 2026Article
- Atypical Development of Functional Brain Networks in Neonates with Congenital Heart Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A null findings study: graph theoretical analysis of the fetal functional connectome shows no relationships with future autistic traits.Neuroimage. Reports · 2026Article
- Fetal functional connectivity prospectively associates with autistic traits in toddlerhood.NeuroImage. Clinical · 2026Article
- Stress during the first 1,000 days of life in humans, when everything begins.Frontiers in human neuroscience · 2026Review
- Utilizing functional neuroimaging to study early language development.Developmental cognitive neuroscience · 2025Review
- Early functional organization of the anterior and posterior hippocampus in the fetal brain.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Maternal Prenatal Psychological Stress and Iron Levels in the Fetal Brain.Developmental psychobiology · 2025Article
- Evaluating the effects of volume censoring on fetal functional connectivity.Scientific reports · 2025Article
- The developing Human Connectome Project fetal functional MRI release: Methods and data structures.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Greater Neighborhood Disadvantage Is Associated with Alterations in Fetal Functional Brain Network Structure.The Journal of pediatrics · 2024Observational
- Trajectories of human brain functional connectome maturation across the birth transition.PLoS biology · 2024Article
- Functional connectivity of the pediatric brain.Neuroradiology · 2024Review
- Advances in Fetal Brain Imaging.Magnetic resonance imaging clinics of North America · 2024Review
- Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy.Molecular psychiatry · 2024Review
- Characterizing Large-Scale Human Circuit Development with In Vivo Neuroimaging.Cold Spring Harbor perspectives in biology · 2024Review
- Altered Functional Connectivity during Mild Transient Respiratory Impairment Induced by a Resistive Load.Journal of clinical medicine · 2024Article
- Deciphering network dysregulations and temporo-spatial dynamics in disorders of consciousness: insights from minimum spanning tree analysis.Frontiers in psychology · 2024Article
- Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Experience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits.BMC medicine · 2023Article
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Authors and funding
9 authors.
Funding
Abstract
Advances in neuroimaging and network analyses have lead to discovery of highly connected regions, or hubs, in the connectional architecture of the human brain. Whether these hubs emerge in utero, has yet to be examined. The current study addresses this question and aims to determine the location of neural hubs in human fetuses. Fetal resting-state fMRI data (N = 105) was used to construct connectivity matrices for 197 discrete brain regions. We discovered that within the connectional functional organization of the human fetal brain key hubs are emerging. Consistent with prior reports in infants, visual and motor regions were identified as emerging hub areas, specifically in cerebellar areas. We also found evidence for network hubs in association cortex, including areas remarkably close to the adult fusiform facial and Wernicke areas. Functional significance of hub structure was confirmed by computationally deleting hub versus random nodes and observing that global efficiency decreased significantly more when hubs were removed (p < .001). Taken together, we conclude that both primary and association brain regions demonstrate centrality in network organization before birth. While fetal hubs may be important for facilitating network communication, they may also form potential points of vulnerability in fetal brain development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.