ReviewDevelopmental biology2018
Wilhelm His' lasting insights into hindbrain and cranial ganglia development and evolution.
Review in Developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
- Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.Neuroscience letters · 2026Article
- An Lmx1a/b allelic series reveals the role of Lmx1 genes in cochlear nuclei development.Cell and tissue research · 2026Article
- Sponge bHLH Gene Expression inInternational journal of molecular sciences · 2025Article
- Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain.Annual review of neuroscience · 2024Review
- Evolution and development of extraocular motor neurons, nerves and muscles in vertebrates.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2024Review
- Gene networks and the evolution of olfactory organs, eyes, hair cells and motoneurons: a view encompassing lancelets, tunicates and vertebrates.Frontiers in cell and developmental biology · 2024Review
- The Development of Speaking and Singing in Infants May Play a Role in Genomics and Dementia in Humans.Brain sciences · 2023Review
- The evolution of the various structures required for hearing inIBRO neuroscience reports · 2023Article
- Early Steps towards Hearing: Placodes and Sensory Development.International journal of molecular sciences · 2023Review
- Molecular mechanisms governing development of the hindbrain choroid plexus and auditory projection: A validation of the seminal observations of Wilhelm His.IBRO neuroscience reports · 2022Review
- Molecular Organization and Patterning of the Medulla Oblongata in Health and Disease.International journal of molecular sciences · 2022Review
- The revolutionary developmental biology of Wilhelm His, Sr.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Vision and retina evolution: How to develop a retina.IBRO neuroscience reports · 2022Article
- Transcription factors regulating the specification of brainstem respiratory neurons.Frontiers in molecular neuroscience · 2022Review
- Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon.Frontiers in neural circuits · 2022Article
- An Integrated Perspective of Evolution and Development: From Genes to Function to Ear, Lateral Line and Electroreception.Diversity · 2021Article
- Development in the Mammalian Auditory System Depends on Transcription Factors.International journal of molecular sciences · 2021Review
- Smoothened overexpression causes trochlear motoneurons to reroute and innervate ipsilateral eyes.Cell and tissue research · 2021Article
- Lmx1a and Lmx1b are Redundantly Required for the Development of Multiple Components of the Mammalian Auditory System.Neuroscience · 2021Article
- Axonal Projection Patterns of the Dorsal Interneuron Populations in the Embryonic Hindbrain.Frontiers in neuroanatomy · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Wilhelm His (1831-1904) provided lasting insights into the development of the central and peripheral nervous system using innovative technologies such as the microtome, which he invented. 150 years after his resurrection of the classical germ layer theory of Wolff, von Baer and Remak, his description of the developmental origin of cranial and spinal ganglia from a distinct cell population, now known as the neural crest, has stood the test of time and more recently sparked tremendous advances regarding the molecular development of these important cells. In addition to his 1868 treatise on 'Zwischenstrang' (now neural crest), his work on the development of the human hindbrain published in 1890 provided novel ideas that more than 100 years later form the basis for penetrating molecular investigations of the regionalization of the hindbrain neural tube and of the migration and differentiation of its constituent neuron populations. In the first part of this review we briefly summarize the major discoveries of Wilhelm His and his impact on the field of embryology. In the second part we relate His' observations to current knowledge about the molecular underpinnings of hindbrain development and evolution. We conclude with the proposition, present already in rudimentary form in the writings of His, that a primordial spinal cord-like organization has been molecularly supplemented to generate hindbrain 'neomorphs' such as the cerebellum and the auditory and vestibular nuclei and their associated afferents and sensory organs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.