ArticleJournal of clinical hypertension (Greenwich, Conn.)2018
Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Masked and white coat hypertension, the double trouble of large arteries: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2020Pooled it
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- Central systolic blood pressure relates inversely to nitric oxide synthesis in young black adults: the African-PREDICT study.Journal of human hypertension · 2021Article
- Circulating Levels of Endothelin-1 and Big Endothelin-1 in Patients with Essential Hypertension.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021Article
- Gut permeability is associated with hypertension and measures of obesity but not with Endothelial Dysfunction in South African youth.African health sciences · 2021Article
- Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses.Current hypertension reports · 2020Review
- Effect of high-altitude trekking on blood pressure and on asymmetric dimethylarginine and isoprostane production: Results from a Mount Ararat expedition.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Endothelial Dysfunction in Patients with Rheumatoid Arthritis: the Role of Hypertension.Current hypertension reports · 2020Review
- Oxidative Stress: A Unifying Paradigm in Hypertension.The Canadian journal of cardiology · 2020Review
- Masked hypertensives: A disguised arterial stiffness population.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Asymmetric dimethylarginine is not a marker of arterial damage in children with glomerular kidney diseases.Central-European journal of immunology · 2019Article
- Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Comparison of biomarkers of endothelial dysfunction and microvascular endothelial function in patients with primary aldosteronism and essential hypertension.Journal of the renin-angiotensin-aldosterone system : JRAASArticle
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10 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Asymmetric dimethylarginine (ADMA) is a robust marker of endothelial dysfunction in patients with essential hypertension. We investigated ADMA levels and their association with vascular damage in untreated hypertension. We enrolled consecutive patients with untreated, recently diagnosed hypertension and age-matched normotensive individuals. 24-hour blood pressure, central hemodynamics, and arterial stiffness were recorded. A total of 311 individuals were studied: 165 with essential hypertension, 50 with masked hypertension, 25 with white-coat hypertension, and 71 normotensive individuals. ADMA levels significantly correlated with aortic augmentation index (AIx75) (r = .156, P = .006), aortic pulse pressure (r = .153, P = .007) and marginally with carotid-femoral pulse wave velocity (r = .110, P = .051), as well as with diastolic office BP. In the multivariate model, aortic AIx75 and age were the only statistically significant predictors of ADMA. This is the largest study to document an independent association between ADMA and aortic AIx75 but not with other indices of arterial stiffness.
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