ArticlePloS one2018
Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 70 citations in OpenAlex.
- Five-Year CT-Based Skeletal Muscle Decline Curves in Cirrhosis According to Liver Functional Reserve and Routinely Available Clinical Factors.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Association between serum bicarbonate and low mid-upper arm circumference in patients with non-dialysis-dependent chronic kidney disease: A cross-sectional study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Serum carboxymethyl-lysine levels inversely correlate with appendicular skeletal muscle index in female patients with non-dialysis chronic kidney disease.BMC nephrology · 2026Article
- Vascular and musculoskeletal interactions: structure, function, and therapeutic strategies for sarcopenia and osteoporosis.MedScience · 2026Review
- Association Between Cellular Hydration Patterns and Hydroelectrolytic Regulation with Muscle Strength in Older Adults.Nutrients · 2026Article
- Pathophysiology and potential treatment of uremic sarcopenia.Kidney research and clinical practice · 2026Article
- Circulating Extracellular Vesicle MicroRNAs as Predictive Biomarkers for Kidney and Cardiovascular Events.Journal of the American Heart Association · 2026Article
- Muscle Quality Assessed by the Phase Angle Can Predict Renal Prognosis in Patients with Chronic Kidney Disease.Journal of clinical medicine · 2025Article
- Changes in body composition and handgrip strength during dapagliflozin administration in patients with chronic kidney disease.Clinical kidney journal · 2025Article
- Quality matters: chronic kidney disease progression is associated with reduced muscle strength independently of changes in skeletal muscle mass: an observational study.Clinical kidney journal · 2025Article
- The impact of high-salt diet and diuretics on the development of the aestival phenomenon in patients with chronic heart failure.Frontiers in nutrition · 2025Article
- Accelerated aging of skeletal muscle and the immune system in patients with chronic liver disease.Experimental & molecular medicine · 2024Article
- Pharmacologic therapeutics in sarcopenia with chronic kidney disease.Kidney research and clinical practice · 2024Article
- Drug-related sarcopenia as a secondary sarcopenia.Geriatrics & gerontology international · 2024Review
- Article
- Association of the number of remaining teeth with kidney function in community-dwelling healthy older adults: a cross-sectional study.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2023Article
- Loop Diuretics and Sarcopenia: A Potential Association.Muscles (Basel, Switzerland) · 2023Review
- Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study.Drugs & aging · 2023Observational
- Sarcopenia in chronic kidney disease: from bench to bedside.The Korean journal of internal medicine · 2023Review
- Factors Associated with Sarcopenia in Patients with Chronic Kidney Disease: A Cross-Sectional Single-Center Study.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSarcopenia, the age-related loss of muscle mass and function, frequently accompanies chronic kidney disease. The aim of this study was to clarify the prevalence and the risk factors for sarcopenia among patients with non-dialysis-dependent chronic kidney disease (NDD-CKD), focusing on the use of drugs.
methodsWe conducted a cross-sectional analysis on a cohort of 260 patients with NDD-CKD in a university hospital, recruited between June 2016 and March 2017. We extracted data on patient gender, age, cause of chronic kidney disease, use of drugs, and comorbidities that could potentially affect the prevalence of sarcopenia. Sarcopenia was diagnosed using the criteria of the Asian Working Group for Sarcopenia. Logistic regression analysis was performed to analyze the association of each factor on the prevalence of sarcopenia.
results25.0% of our study subjects had sarcopenia. Multivariable analysis revealed that an increased risk of sarcopenia was significantly associated with age, male gender, body mass index, diabetes mellitus, and loop diuretic use (odds ratio, 4.59: 95% confidence interval, 1.81-11.61: P-value 0.001).
conclusionsIn our cohort, the prevalence of sarcopenia in patients with NDD-CKD was high, and diuretics use, particularly loop diuretic use, was suggested to be a risk factor of sarcopenia. Although loop diuretics are commonly used in patients with CKD, careful consideration of the risk of sarcopenia may be necessary.
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