ArticlePloS one2018
Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 79 citations in OpenAlex.
- Propofol-Induced Mitochondrial Dysfunction Is Independent of Mitochondrial Permeability Transition.Biomedicines · 2025Article
- Incidence, severity, and predictors of citrate accumulation during continuous kidney replacement therapy in the critically ill.Critical care (London, England) · 2025Article
- Fluorescence lifetime imaging to investigate propofol-induced metabolic alterations in MDA-MB-231 cells.Biomedical optics express · 2025Article
- Anesthetic-Induced Disruption of Amino Acid and Carnitine Profiles: A Metabolomic Comparison of Propofol and Thiopental in Hepatocytes.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Dexmedetomidine suppresses glucose-stimulated insulin secretion in pancreatic β-cells.FEBS open bio · 2025Article
- Renal mitochondria response to sepsis: a sequential biopsy evaluation of experimental porcine model.Intensive care medicine experimental · 2025Article
- Anesthesia-related factors in the pathogenesis of postoperative cognitive dysfunction: a mechanistic perspective.Frontiers in neurology · 2025Article
- Propofol-related biological alterations and incidence of propofol infusion syndrome in status epilepticus: a 10-year cohort study.Frontiers in neurology · 2025Article
- Article
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- Propofol-Related Infusion Syndrome: A Bibliometric Analysis of the 100 Most-Cited Articles.Cureus · 2023Review
- Propofol elicits apoptosis and attenuates cell growth in esophageal cancer cell lines.Nagoya journal of medical science · 2023Article
- Modulatory dynamics mark the transition between anesthetic states of unconsciousness.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Propofol inhibits neuroinflammation and metabolic reprogramming in microgliaFrontiers in pharmacology · 2023Article
- Propofol suppresses cell proliferation in gastric cancer cells through NRF2-mediated polyol pathway.Clinical and experimental pharmacology & physiology · 2022Article
- Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles.BMC molecular and cell biology · 2021Article
- Hypoxia-dependent signaling in perioperative and critical care medicine.Journal of anesthesia · 2021Review
- Lung but not brain cancer cell malignancy inhibited by commonly used anesthetic propofol during surgery: Implication of reducing cancer recurrence risk.Journal of advanced research · 2021Article
- Prophylactic Melatonin Treatment Ameliorated Propofol-Induced Cognitive Dysfunction in Aged Rats.Neurotoxicity research · 2021Article
- Propofol regulates activated macrophages metabolism through inhibition of ROS-mediated GLUT1 expression.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia and sedation in critical patient care. However, the rare but severe complication propofol infusion syndrome (PRIS) can occur, especially in patients receiving high doses of propofol for prolonged periods. In vivo and in vitro evidence suggests that the propofol toxicity is related to the impaired mitochondrial function. However, underlying molecular mechanisms remain unknown. Therefore, we investigated effects of propofol on cell metabolism and death using a series of established cell lines of various origins, including neurons, myocytes, and trans-mitochondrial cybrids, with defined mitochondrial DNA deficits. We demonstrated that supraclinical concentrations of propofol in not less than 50 μM disturbed the mitochondrial function and induced a metabolic switch, from oxidative phosphorylation to glycolysis, by targeting mitochondrial complexes I, II and III. This disturbance in mitochondrial electron transport caused the generation of reactive oxygen species, resulting in apoptosis. We also found that a predisposition to mitochondrial dysfunction, caused by a genetic mutation or pharmacological suppression of the electron transport chain by biguanides such as metformin and phenformin, promoted propofol-induced caspase activation and cell death induced by clinical relevant concentrations of propofol in not more than 25 μM. With further experiments with appropriate in vivo model, it is possible that the processes to constitute the molecular basis of PRIS are identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.