ArticlePloS one2018
Euglena extract suppresses adipocyte-differentiation in human adipose-derived stem cells.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Variable Bioproduction with Euglena gracilis: A Function of Light Flux or Carbon Source, Supplements, and Time.Advances in biochemical engineering/biotechnology · 2025Review
- Article
- The impact of elevated sulfur and nitrogen levels on cadmium tolerance in Euglena species.Scientific reports · 2024Article
- Thymoquinone: A comprehensive review of its potential role as a monotherapy for metabolic syndrome.Iranian journal of basic medical sciences · 2024Review
- Activation of Immune and Antiviral Effects byFoods (Basel, Switzerland) · 2023Review
- Effects of Thymoquinone on Adipocyte Differentiation in Human Adipose-Derived Stem Cells.Cell biochemistry and biophysics · 2022Article
- Antiviral Activity and Underlying Action Mechanism of Euglena Extract against Influenza Virus.Nutrients · 2021Article
- Anti-Inflammatory Activities ofMicroorganisms · 2021Article
- Mechanism of the fungal-like particles in the inhibition of adipogenesis in 3T3-L1 adipocytes.Scientific reports · 2021Article
- The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation.Scientific reports · 2021Article
- Article
- Anti-Obesity Effects of Microalgae.International journal of molecular sciences · 2019Review
- Unlocking the Antiadipogenic Potential of Carotenoids From Galdieria phlegrea.BioFactors (Oxford, England)Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Euglena gracilis Z (Euglena) is a unicellular, photosynthesizing, microscopic green alga. It contains several nutrients such as vitamins, minerals, and unsaturated fatty acids. In this study, to verify the potential role of Euglena consumption on human health and obesity, we evaluated the effect of Euglena on human adipose-derived stem cells. We prepared a Euglena extract and evaluated its effect on cell growth and lipid accumulation, and found that cell growth was promoted by the addition of the Euglena extract. Interestingly, intracellular lipid accumulation was inhibited in a concentration-dependent manner. Quantitative real-time PCR analysis and western blotting analysis indicated that the Euglena extract suppressed adipocyte differentiation by inhibiting the gene expression of the master regulators peroxisome proliferator-activated receptor-γ (PPARγ) and one of three CCAAT-enhancer-binding proteins (C/EBPα). Further Oil Red O staining experiments indicated that the Euglena extract inhibited the early stage of adipocyte-differentiation. Consistent with these results, we observed that down-regulation of gene expression was involved in the early stage of adipogenesis represented by the sterol regulatory element binding protein 1 c (SREBP1c), two of three CCAAT-enhancer-binding proteins (C/EBPβ, C/EBPδ), and the cAMP regulatory element-binding protein (CREB). Taken together, these data suggest that Euglena extract is a promising candidate for the development of a new therapeutic treatment for obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.