Evidence map›Paper›PMID 29447072›Full record

ArticleJournal of biomolecular structure & dynamics2019

Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA.

Rui Wang, Srivathsan V Ranganathan, Phensinee Haruehanroengra, Song Mao, Matteo Scalabrin, Daniele Fabris, Alan Chen, Hehua Liu, Abdalla E A Hassan, Jianhua Gan and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Rui Wanga Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
Srivathsan V Ranganathanb The RNA Institute , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
Phensinee Haruehanroengraa Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
Song Maoa Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
Matteo Scalabrina Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
Daniele Fabrisa Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
Alan Chena Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
Hehua Liuc State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences , Fudan University , Shanghai 200433 , China.
Abdalla E A Hassand Applied Nucleic Acids Research Center, Faculty of Science , Zagazig University , Zagazig , Egypt.
Jianhua Ganc State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences , Fudan University , Shanghai 200433 , China.
Jia Shenga Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
Albany State University · USUniversity at Albany, State University of New York · USFudan University · CNState Key Laboratory of Genetic EngineeringZagazig University · EG

Funding

Structural determinants of HIV-1 5'-UTR riboswitch and NC actuation by MS3DR01GM064328 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI FABRIS, DANIELE · 2001 to 2013
$3.8M
Characterization of ncRNAs' post-transcriptional modifications by antisense affinity capture and MS analysisR01GM121844 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI FABRIS, DANIELE · 2017 to 2021
$1.6M
Environmental Epitranscriptomic Studies and Tools Focused on the Wobble UridineR15GM124627 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI SHENG, JIA · 2017 to 2017
$443k
MS-based screening of candidate inhibitors of protein-RNA and RNA-RNA interactionR21NS063871 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI FABRIS, DANIELE · 2008 to 2008
$148k
NIGMS NIH HHS R01 GM064328NIGMS NIH HHS R01 GM121844NIGMS NIH HHS R15 GM124627NINDS NIH HHS R21 NS063871
6 · The paper itself

Abstract

The facile construction of metal-DNA complexes using 'Click' reactions is reported here. A series of 2'-propargyl-modified DNA oligonucleotides were initially synthesized as structure scaffolds and were then modified through 'Click' reaction to incorporate a bipyridine ligand equipped with an azido group. These metal chelating ligands can be placed in the DNA context in site-specific fashion to provide versatile templates for binding various metal ions, which are exchangeable using a simple EDTA washing-and-filtration step. The constructed metal-DNA complexes were found to be thermally stable. Their structures were explored by solving a crystal structure of a propargyl-modified DNA duplex and installing the bipyridine ligands by molecular modeling and simulation. These metal-DNA complexes could have wide applications as novel organometallic catalysts, artificial ribonucleases, and potential metal delivery systems.

Indexed as

2,2'-DipyridylClick ChemistryCrystallography, X-RayDNAIonsLigandsMetalsMolecular Dynamics SimulationMolecular WeightNucleic Acid DenaturationNucleic Acid HeteroduplexesOligonucleotidesTemperature2,2'-DipyridylDNAIonsLigandsMetalsNucleic Acid HeteroduplexesOligonucleotidesclick reactionDNA materialDNA scaffoldmetallic DNApropargyl-DNA

Identifiers

PMID29447072
PMCPMC6715418
OpenAlexW2792471731

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.