ArticleJournal of the American Chemical Society2018
Enantioselective Intermolecular Pd-Catalyzed Hydroalkylation of Acyclic 1,3-Dienes with Activated Pronucleophiles.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Outcompeting hydrofunctionalization: Asymmetric remote substitution of alkynes.Science advances · 2025Article
- Ligand-controlled divergent enantioselective hydroarylation of cyclobutenes.Chemical science · 2025Article
- Disubstituted Meldrum's Acid: Another Scaffold with SuFEx-like Reactivity.Molecules (Basel, Switzerland) · 2025Article
- Palladium-Catalyzed Regiodivergent Three-Component Alkenylamination of 1,3-Dienes with Alkyl and Aryl Amines.Journal of the American Chemical Society · 2023Article
- Escape from Hydrofunctionalization: Palladium Hydride-Enabled Difunctionalization of Conjugated Dienes and Enynes.Angewandte Chemie (International ed. in English) · 2023Article
- Metal-Catalyzed Enantioconvergent Transformations.Chemical reviews · 2023Review
- Copper-Catalyzed Asymmetric Acylboration of 1,3-Butadienylboronate with Acyl Fluorides.Angewandte Chemie (International ed. in English) · 2023Article
- Asymmetric formal spNature communications · 2023Article
- Synthesis of Allenes by Hydroalkylation of 1,3-Enynes with Ketones Enabled by Cooperative Catalysis.Journal of the American Chemical Society · 2023Article
- Palladium-catalyzed enantioselective rearrangement of dienyl cyclopropanes.Chemical science · 2023Article
- Nickel-catalyzed regio- and enantio-selective Markovnikov hydromonofluoroalkylation of 1,3-dienes.Chemical science · 2022Article
- Synergistic Pd/Cu-catalyzed enantioselective CspNature communications · 2022Article
- Nickel/Brønsted acid dual-catalyzed regio- and enantioselective hydrophosphinylation of 1,3-dienes: access to chiral allylic phosphine oxides.Chemical science · 2022Article
- Direct access to spirocycles by Pd/WingPhos-catalyzed enantioselective cycloaddition of 1,3-enynes.Nature communications · 2021Article
- Palladium-catalyzed regio- and enantioselective migratory allylic C(spNature communications · 2021Article
- α- and β-Functionalized Ketones from 1,3-Dienes and Aldehydes: Control of Regio- and Enantioselectivity in Hydroacylation of 1,3-Dienes.Journal of the American Chemical Society · 2021Article
- Further Developments and Applications of Oxazoline-Containing Ligands in Asymmetric Catalysis.Chemical reviews · 2021Article
- Recent Advances in Enantioselective Pd-Catalyzed Allylic Substitution: From Design to Applications.Chemical reviews · 2021Article
- Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes.Molecules (Basel, Switzerland) · 2021Review
- Palladium-catalyzed dearomative 1,4-difunctionalization of naphthalenes.Chemical science · 2020Article
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3 authors.
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Abstract
We report a highly enantioselective Pd-PHOX-catalyzed intermolecular hydroalkylation of acyclic 1,3-dienes. Meldrum's acid derivatives and other activated C-pronucleophiles, such as β-diketones and malononitriles, react with a variety of aryl- and alkyl-substituted dienes in ≤20 h at room temperature. The coupled products, obtained in up to 96% yield and 97.5:2.5 er, are easily transformed into useful chemical building blocks for downstream synthesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.