Evidence map›Paper›PMID 29446830›Full record

Trial reportThe Journal of physiology2018

Prior ingestion of exogenous ketone monoester attenuates the glycaemic response to an oral glucose tolerance test in healthy young individuals.

Étienne Myette-Côté, Helena Neudorf, Hossein Rafiei, Kieran Clarke, Jonathan Peter Little

Erratum issued 2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04156477 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Markers of Appetite Regulation During Exogenous Ketosis - a Placebo Controlled Randomized Study of Appetite Regulatory and Metabolic Markers After Intake of a Keto- or Glucogenic Drink.

TypeinterventionalSponsorCentral Jutland Regional HospitalRan2019 to 2019Enrolled10ConditionsKetosisArmsKetone ester, Glucose, Tap water
NCT04487678 nawithdrawnnot on this mapstarted 2023, after this paper: background citation

A Single-centre, Randomised, Single-blinded Crossover Study Evaluating the Metabolic Effects of a Ketone Ester Food Supplement in People With Type 1 Diabetes

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2023 to 2023Enrolled0ConditionsKetosis, DiabeticArmsKetone ester supplement
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

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  17. Dietary tributyrin supplementation in Parkinson's disease: An open-label target engagement study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Étienne Myette-CôtéSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Helena NeudorfSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Hossein RafieiSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Kieran ClarkeDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK.
Jonathan Peter LittleSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.ORCID 0000-0002-9796-2008
University of British Columbia · CAUniversity of Oxford · GB

Funding

CIHR MSH‐141980
6 · The paper itself

Abstract

key pointsThe recent development of exogenous ketone supplements allows direct testing of the metabolic effects of elevated blood ketones without the confounding influence of widespread changes experienced with ketogenic diets or prolonged fasting. In the present study, we determined the effect of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester on the glycaemic response and insulin sensitivity index during a 2 h oral glucose tolerance test (OGTT) in humans. The results obtained show that consuming a ketone monoester supplement 30 min prior to an OGTT reduced the glycaemic response and markers of insulin sensitivity without affecting insulin secretion. The findings of the present study provides evidence that ketone supplements could have therapeutic potential for future application as a glucose-lowering nutritional supplement. ABSTRACT: The main objectives of the present study were: (i) to determine whether acute ingestion of ketone monoester (K

Indexed as

Insulin ResistanceAdolescentAdultBlood GlucoseDietary SupplementsFemaleHumansHydroxybutyratesHyperglycemiaHypoglycemic AgentsMaleBlood GlucoseHydroxybutyratesHypoglycemic Agents(R)-3-hydroxybutyl (R)-3-hydroxybutyrated-beta-hydroxybutyrateglycemic responseinsulin sensitivityketone bodiesnon-esterified fatty acids

Identifiers

PMID29446830
PMCPMC5899975
OpenAlexW2790581874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.